angiotensin II antagonists. angiotensin receptor antagonists (ARA) or blockers (ARB)

Question 1

MOA

Answer 1

Competitively block binding of angiotensin II to type 1 angiotensin (AT1) receptors.

They reduce angiotensin II-induced vasoconstriction, sodium reabsorption and aldosterone release. They also reduce the effect of angiotensin II on sympathetic nervous activity and growth factors

(Ref: AMH)

Question 2

Side effects?

Answer 2

dizziness, headache, hyperkalaemia

Ref: AMH

Question 3

Which sartans are marketed to reduce progression enal disease in patients who have type 2 diabetes, hypertension and proteinuria (also microalbuminuria for irbesartan)?

Answer 3

Losartan and irbesartan

Ref: AMH

Question 4

Sartans do not cause cough like ACE I’s, why is this?

Answer 4

Sartans do not inhibit the breakdown of bradykinin and