Anesthesia Flashcards
What does a low ETCO2 indicate?
LOW ⬇️ ETCO2 indicates:
POOR SYSTEMIC PERFUSION, which can be caused by
- HYPOVOLEMIA (low blood volume)
- SEPSIS SHOCK
- DYSRHYTHMIAS
- CARDIAC ARREST (no CO2 production)
- HYPER-ventilation.
Dosage for Ketamine
Induction with 2 mg/kg of ketamine usually produces 15 to 30 minutes of unconsciousness within seconds.
Ketamine may also be administered:
- rectally at 10 mg/kg,
- orally at 6 to 10 mg/kg, or
- intranasally at 3 to 6 mg/kg to induce anesthesia.
What is Alveolar Dead 💀 Space?
🚫⛽️ .3
DEAD SPACE 💀
- ALVEOLI which have little or NO BLOOD flowing through their adjacent PULMONARY CAPILLARIES
- ALVEOLI that are VENTILATED but NOT PERFUSED
-The VOLUME of air that is INHALED that does NOT 🚫 take part in the GAS ⛽️ EXCHANGE
In HUMANS, about a THIRD (1/3) of every resting breath has no change in O2 and CO2 levels.
In adults, it is usually in the range of 150 mL
What does high ETCO2 indicate?
An ELEVATED ⬆️ EtCO2 level indicates:
- INCREASE ⬆️ in alveolar dead space
- INCREASE ⬆️ metabolic activity.
- HYPOventilation
- HYPOtension (hemorrhage, pump failure, anaphylaxis, etc.)
What is Ketamine? Properties?
Ketamine is a DISSOCIATIVE ANESTHETIC
- has a RAPID ONSET and a SHORT DURATION of action, causes CENTRAL DISLOCATION while providing ANALGESIA and AMNESIA.
- does NOT significantly affect blood pressure and/or cardiac output. ↔️ BP/CO
- INCREASES the production of ⬆️ SECRETIONS, anticholinergic medications (e.g., atropine, glycopyrrolate) are usually needed.
-DREAMS and HALLUCINATIONS 👻🧠 are the most common side effects associated with ketamine: 5% to 10% of prepubescent children and 30% to 50% of ⬆️ OLDER children experience this adverse effect.
Administration of a BENZODIAZEPINE concomitantly with ketamine ⬇️ DECREASES the incidence of dreams and hallucinations.
Contraindications to the use of ketamine:
- active upper RESPIRATORY tract infection 🤧
- INCREASED ⬆️ intracranial pressure, open-globe injury,
- PSYCHIATRIC or seizure disorders.🤪
What is Malignant Hypothermia?
Temp - Cont - AD
Malignant hyperthermia (MH) is a disease that causes a FAST RISE in body TEMPERATURE and SEVERE MUSCLE CONTRACTIONS when someone with MH gets GENERAL ANESTHESIA
MH is passed down through FAMILIES.
AD; Autosomal Dominant
What is the reversal agent for Malignant Hypothermia?
DANTROLENE
2.5 mg/kg rapid IV bolus, repeat PRN
produces RELAXATION of skeletal MUSCLE without causing complete paralysis, and is the only xenobiotic proven to be effective for both treatment and prophylaxis of malignant hyperthermia (MH).
What are signs of Malignant Hypothermia?
Early clinical signs of MH:
- ⬆️ INCREASE in end-tidal CARBON DIOXIDE (even with increasing minute ventilation),
- Tachycardia
- Tachypnea (breathing rapid/shallow)
- Muscle rigidity
- Hyperkalemia.
Later signs:
- Fever
- Myoglobinuria (myoglobin in urine)
- Multiple organ failure.
What triggers Malignant Hyperthermia?
- ALL INHALED General Anesthetics:
Sevoflurane, Isoflurane, Halothane
Chloroform (Trichloromethane, Methyltrichloride) Desflurane. Enflurane. Methoxyflurane.. Trichloroethylene. Xenon.
- *N20 is OK**
- *IV (Propofal) OK**
- SUCCINYLCHOLINE
Depolarizing muscle relaxants.
What is Propofol dosage?
INDUCTION DOSE:
higher in ⬆️ YOUNGER patients (2.9 mg/kg for children less than 2 years of age)
than in ⬇️ OLDER patients (2.2 mg/kg for patients 6 to 12 years of age)
What is Propofol? Properties?
PROPOFOL: sedative-hypnotic agent
- most commonly used IV INDUCTION AGENT in pediatric anesthesia.
- very rapid onset and is associated with a REDUCED rate of postoperative NAUSEA and VOMITING. ⬇️🤢🤮⬇️
- associated with PAIN🥺 on IV administration, particularly in small veins. (Emla cream/Lido)
- After induction, propofol is considered a useful agent for MAINTAINING hypnosis and amnesia. It can be used as a SOLE anesthetic AGENT for nonpainful procedures.
What is the normal range for End-Tidal Co2
35-45 mm HG
What increases ⬆️ Alveolar Dead Space?💀
⬆️⬆️⬆️ Dead Space 💀💀💀
- Airway diseases: ASTHMA 😬, bronchitis, emphysema 🚬
- Right-to-Left shunt. ➡️2⬅️💔
-Tetralogy of Fallot
-Tricuspid Atresia
-Transposition of Great Vessels
(CYANOT.T.T.IC 🥶) - Pulmonary Embolism, Pulmonary Hypotension
What does Ventilation and Perfusion mean?
GAS ⛽️ EXCHANGE occurs in the lungs between alveolar air and blood of the pulmonary capillaries.
For effective gas exchange to occur, ALVEOLI must be ventilated and perfused.
VENTILATION 💨 (V) refers to the FLOW OF AIR into and out of the alveoli
PERFUSION 🔴 (Q) refers to the FLOW OF BLOOD to alveolar capillaries.
The ratio of ventilation to perfusion (V/Q). Changes in the V/Q ratio can affect gas exchange and can contribute to hypoxemia.
HIGH V/Q ratio decreases pCO2 ⬇️ and increases pO2.⬆️ (TACHYPNEA)
What is the normal partial pressure for O2 (PaO2) in Blood.
The normal partial pressure reference value for oxygen: PaO2 more than 80 mmHg
A drop in the oxygen carried in blood is known as HYPOXEMIA
What’s the difference between Hypoxia and Hypoxemia.
The term hypoxia and hypoxemia are not synonymous.
- HYPOXEMIA is defined as a DECREASE ⬇️ in the PARTIAL PRESSURE of oxygen in the BLOOD whereas
- HYPOXIA is defined by REDUCED ⬇️ level of TISSUE oxygenation.
T/F Nail Polish can effect a Pulse Oximeter?
True
What happens with Methemoglobinemia?
Hemoglobin is the protein in red blood cells (RBCs) that carries and distributes oxygen to the body. Methemoglobin is a form of hemoglobin.
MetHb
With methemoglobinemia, the hemoglobin can carry oxygen, but is NOT ABLE TO RELEASE it effectively to body tissues.
What is the danger of topical anesthetics containing Benzocaine for children 👶 under 24 months?
The U.S. Food and Drug Administration (FDA) is warning the public that the use of benzocaine, the main ingredient in over-the-counter (OTC) gels and liquids applied to the gums or mouth to reduce pain, is associated with a rare, but serious condition. This condition is called METHEMOGLOBINIA and results in the amount of oxygen carried through the blood stream being greatly reduced. In the most severe cases, methemoglobinemia can result in death.
Methemoglobinemia has been reported with all strengths of benzocaine gels and liquids, including concentrations as low as 7.5%. The cases occurred mainly in children aged TWO YEARS OR YOUNGER who were treated with benzocaine gel for TEETHING.
What are the signs of Methemoglobinia?
Gray or blue colored skin,🥶 lips, and nail beds Shortness of breath 🌬 fatigue 😑 confusion 🤪 headache 🤕 lightheadedness ☁️ and rapid heart rate 💓
The signs and symptoms usually appear within minutes to hours of applying BENZOCAINE and may occur with the first application of benzocaine or after additional use. If you or your child has any of these symptoms after taking benzocaine, seek medical attention immediately
Contraindications for General Anesthesia
- Risks outweigh proposed procedure
- Respiratory infection 🤧
- Active systemic disease with elevated temperature 🤒
- NPO violation 🍎
- Medical conditions / Lab Values that contraindication for GA ⛑
What values does a pulse oximeter measure?
What can it NOT measure?
MEASURES: peripheral oxygen saturation (SpO2)
More specifically, it measures what percentage of hemoglobin, the protein in blood that carries oxygen, is loaded.
Acceptable normal ranges for patients without pulmonary pathology are from 95 to 99 percent
CANNOT Measure: it cannot determine the METABOLISM of oxygen, or the AMOUNT of oxygen being used by a patient. For this purpose, it is necessary to also measure carbon dioxide (CO2) levels.
O2 Saturation (SaO2) determines what?
SaO2
the percentage of AVAILABLE BINDING sites on HEMOGLOBIN that are bound with oxygen in ARTERIAL blood.