anatomy and physiology exam two Flashcards
integument
SKIN: largest organ in the human body and one of the excretory organs
free nerve endings
detect pain via receptors; respond to pain, tickle, temperature, and itch sensations
arrector pili (smooth muscle)
involuntary; contracts and causes hair to stand up when cold, scared, or during a revelation moment (AHA!)
sebaceous gland
produces oil to keep skin from flaking; adds to protection of the skin itself
sudoriferous gland
sweat
adipose tissue
fat; provides energy storage, insulation, and padding
layers of epidermis (superficial to deep)
stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, stratum basale
what layers of the epidermis are dead?
stratum corneum and stratum lucidum
what layers of the epidermis are alive?
stratum spinosum and stratum basale
what layer of the epidermis is moribund?
stratum granulosum
moribund
dying state; apoptosis; near death
direction of cell movement in epidermis
deep to superficial
melanin
pigment; associated with what can we do with electromagnetic radiation, which can introduce mutations
layers of the dermis (superficial to deep)
papillary layer, reticular layer
eccrine sudoriferous (sweat) glands
all over the ENTIRE body; ONLY sweat;
apocrine sudoriferous (sweat) glands
more oil in the sweat secretions (oil + sweat); found in the axillary (arm pit) and groin regions
activated when nervous
apocrine sweat glands secrete oil that stimulates what?
bacterial growth = SMELLS BAD due to substances bacteria are producing
what is the function of skull sinuses?
warming and humidifying the air we breathe in, as well as the secretion of mucus to trap impurities
what are the four skull sinuses?
frontal sinus, ethmoidal labyrinth (sinuses), sphenoidal sinus, maxillary sinus
what organ is responsible for producing vitamin D?
skin: during exposure to sunlight, ultraviolet radiation penetrates into the epidermis and photolyze pro-vitamin D3 to pre-vitamin D3
proprioception
denotes your body’s sense of position, direction and acceleration
many different signals throughout the body that tell us what is going on (where we are, where we are going, when we are moving, how we are moving, etc.)
what part of the ear is involved in proprioception?
inner ear fluid, *pacinian corpuscles, semicircular rings, vestibulocochlear nerve VIII, tiny hairs within ear
what major arteries are exposed?
carotid (neck), jugular (neck), and femoral arteries (groin)
*they are more prone to injury and massive blood loss because they are superficial rather than being deep like other arteries
keratin
tough intermediate filaments that make up scales, hair, nails, feathers, horns, claws, hooves, and the outer layer of skin among vertebrates
keratin function
protects epithelial cells from damage or stress because it is already dead; is extremely insoluble in water and organic solvents
excessive keratinization
participate in fortification of certain tissues such as horns
how long does it take for cells to move from stratum basale to stratum corneum?
45 DAYS!!!
cells are pushed up by new live cells coming up behind them (mitotic activity is occurring)
desmosomes
little “spot welds” between cells that hold them together
gap junctions
allow for intracellular fluid and ions to flow between cells (exchange)
which is thicker, the dermis or epidermis?
dermis
thick epidermis
“thick skin” that form calluses in the palms or soles of feet
where can we find the thickest combination of thick dermis AND epidermis (starts at birth)?
in the skin between our scapulae
obligate aerobes
use oxygen as the terminal electron acceptor of the E.T.C.: oxygen reduced to water
*need oxygen to survive
what are the three enzymes in obligate aerobes?
catalase, superoxide dismutase (S.O.D), glutathione peroxidase (GPx)
what houses the three enzymes found in obligate aerobes?
peroxisome
what happens when there is a cut in the skin and we pour hydrogen peroxide (H2O2) into the cut?
hydrogen peroxide is converted into water and oxygen which kills obligate anaerobes that can cause infections (oxygen is poison to obligate anaerobes)
peroxisomal membrane degradation
peroxisome is damaged by cuts and the enzymes get out of peroxisome and move into the cut
superoxide dismutase (SOD)
makes hydrogen peroxide (H2O2) from the reactive oxygen metabolites
catalase and glutathione peroxidase (GPx)
break H2O2 down into water and oxygen because oxygen is a reactive molecules and aerobes make plenty of reactive oxidative intermediates using oxygen
what are the three elements of cleaning a wound with hydrogen peroxide (H2O2)?
- fluid (liquid) cleaning element
- bubbles of O2 in contact of obligate anaerobe (kills them)
- psychosomatic element
GPx
glutathione peroxidase
GSH
glutathione: tripeptide antioxidant in plants, animals, fungi and some bacteria
prevents oxidative damage via reactive oxygen species to certain parts of the cell
obligate anaerobes
do NOT need oxygen to survive; oxygen is TOXIC
how does glutathione protect cells?
neutralizes the reactive oxygen species by reducing the cysteinyl residue (thiol (sulfur) side chain)
glutathione
tripeptide that consists of glutamate, cysteine, and glycine
most ubiquitous tripeptide; is a potent free radical scavenger
melanin - sunburns - damage of epidermis and dermis - peeling - _____
cancer
what are three types of cancers?
basal cell carcinoma, squamous cell carcinoma, melanoma
basal cell carcinoma
starts in stratum basale; slow growing; LEAST in terms of lethality
squamous cell carcinoma
starts in stratum spinosum
melanoma
starts in melanocyte or might start as a mole; often will metastasize; WORST in terms of lethality
ABCDE of moles
asymmetry, border, color, diameter, evolution
changes to a mole
parts of the human nail
nail plate, nail groove, lunula, eponychium
eponychium
cuticle: extension of the stratum corneum from the proximal nail fold
cholecalciferol (vitamin D3)
formed naturally in the skin when exposed to sunlight, then is modified in the liver, and then final modification occurs in the kidneys to produce calcitriol (active vitamin D)
first-degree burn
epidermis
second-degree burn
epidermis and dermis
third-degree burn
epidermis, dermis, and subcutaneous tissue
immunosuppresant
allows skin graft to not be “tagged as foreign” so it can “take” and not be rejected
no _____ match between the recipient (patient) and donor may lead to new skin graft being rejected
major histocompatibility complex
major histocompatibility complex (MHC)
recognize cells/tissues as self
debridement
cleaning or getting rid of all superflous excess tissue (or dead tissue) because we don’t want prokaryotes to have any sort of headstart of metabolism or truckload of energy
doctors remove dead tissue from a wound to allow for healing and inhibit bacteria growth (can cause infection)
how is a scar connected to epidermal growth factor (EGF)?
macrophages, around a wound, signal fibroblast activity adding collagen and other elements of the extracellular matrix because EGF alone cannot heal these wounds since they are too big
scar
macrophages signaling fibroblast activity around a wound for addition of collagen
COVID-19
leads to inflammation, but when overzealous can cause increased fluid concentration in lungs (pneumonia)
where is COVID-19 + inflammation found in the body?
binds to ACE-2 receptors in the lungs; inflammation then leads to fluid build up and drowning (pneumonia)
hernia
abnormal exit of tissue or an organ, such as the bowel, through the wall of the cavity in which it normally resides
inguinal hernias
present as bulges in the groin due to lifting something too heavy
epigastric hernias
present in the stomach (upper abdomen)
lateral hernias
present in lateral abdomen
femoral hernias
present in upper thigh
incisional hernias
present at the front of the abdomen where a previous incision is located
umbilical hernias
present in or near the belly button
acrochordons (skin tags)
creases in the skin; elevated friction (causes friction of skin)
where are acrochordons found?
neck, axillary region, eyelids, groin
palpabrail
eyelids
antiperspirants
inhibit apocrine sweat glands, decreasing the amount of sweat and oil excreted
deoderants
neutralize the thiol alcohols (sulfur) that produce a bad smell (masks odor)
what is the purpose (function) of inflammation?
to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, and initiate tissue repair
*defenses are good, right up until they are NOT good”
what are the five cardinal signs of inflammation?
heat, pain, redness, swelling, and loss of function
what is the relationship between stress and cortisol?
when stressed, cortisol levels go up so immune system function goes down; body cannot fight off viruses easily and is therefore susceptible to illness
cortisol
stress hormone from the adrenal cortex; only good for short periods of time
interstitium
space between cells
interstitial fluid
fluid in the space between cells
hydroxyapatite (HA)
inorganic matrix; provides compression and tensile strength
formula of hydroxyapatite
Ca10(PO4)6OH2
collagen
triple helix that will form fibrils which then form larger fibrils for strength
compression strength
bone is hard (hydroxyapatite)
tensile strength
like a rope (collagen)
a bone without HA will _____
bend
bones decay when buried in dirt for extended periods of time, so bones lose organic components and water, therefore becoming _____
brittle