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Pharmacology Fall 2016 > Aminoglycosides > Flashcards

Aminoglycosides Flashcards

1
Q

True or False: Aminoglycosides are primarily oral drugs.

A

FALSE - aminoglycosides are pretty much only injectable drugs.

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2
Q

What is the MOA of the aminoglycosides?

A

30S inhibitors

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3
Q

Is the MOA of the aminoglycosides reversible or irreversible? Bacteriostatic or bactericidal?

A

Irreversible –> Bactericidal

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4
Q

Are Aminocyclitols bacteriostatic or bactericidal?

A

Bacteriostatic

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5
Q

What is the spectrum of the aminoglycosides?

A
  1. Gram (-) aerobes

2. Gram (+) cocci

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6
Q

Against which group of organisms are the aminoglycosides useless?

A

Anaerobes

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7
Q

____ and ____ (Aminoglycosides) have activity vs. Pseudomonas.

A

Tobramycin and Amikacin

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8
Q

The combination of ____ and ____ WAS the gold standard vs. Pseudomonas.

A

Tobramycin and Ticarcillin

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9
Q

What is the MOST nephrotoxic aminoglycoside?

A

Neomycin

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10
Q

Which 3 aminoglycosides are most frequently associated with cochlear toxicity?

A
  1. Kanamycin
  2. Amikacin
  3. Neomycin
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11
Q

Which 3 aminoglycosides are most frequently associated with vestibulopathies?

A
  1. Streptomycin
  2. Tobramycin
  3. Gentamycin
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12
Q

Which is observed with aminocyclitols, cochlear toxicity or vestibulopathies?

A

NEITHER

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13
Q

Which is observed more in dogs, cochlear toxicity or vestibulopathies associated with aminoglycoside use?

A

Cochlear toxicity

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14
Q

Which is observed more in cats, cochlear toxicity or vestibulopathies associated with aminoglycoside use?

A

Vestibulopathies

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15
Q

One side effect of Aminoglycosides is neuromuscular blockade. This is associated with the inhibition of what?

A

nAch receptors

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16
Q

What are 2 treatment options for neuromuscular blockade associated with Aminoglycosides?

A
  1. Calcium gluconate

2. Neostigmine

17
Q

Aminoglycosides are MOST incompatible with what?

A

Beta-lactams

18
Q

With Aminoglycosides, which is more important: time above MIC or concentration above MIC?

A

Concentration above MIC

19
Q

True or False: Aminoglycosides are polar compounds.

A

TRUE

20
Q

Aminoglycosides have a low or high Vd?

A

Low Vd

21
Q

What is Paromomycin used against?

A

Cryptosporidium

22
Q

According to the VFD, ____ is the only feed grade aminoglycoside.

A

Neomycin

Pharmacology Fall 2016 (17 decks)

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