Amelogenesis & Enamel- Exam 1 Flashcards

1
Q

Enamel is considered a ____ tissue

A

acellular tissue

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2
Q

Describe the collagen in the matrix in enamel

A

not present

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3
Q

The formation of enamel involves the secretory and resorptive activities of _____ derived cells

A

ectodermally

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4
Q

Compare the strength of enamel vs. dentin:

A

enamel is 5x harder than dentin

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5
Q

What is the hardest tissue in the body?

A

enamel

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6
Q

The core of enamel is comprised of:

A

hydroxyappetite crystals

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7
Q

The calcium hydroxyappetite crystals in enamel are highly oriented and packed into rod-like structures called:

A

enamel rods

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8
Q

Although 96% mineral, the basic rod structure of enamel exhibits some degree of:

A

flexibility

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9
Q

Describe the orientation of enamel rods:

A

parallel to the long axis

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10
Q

Describe the composition of enamel:

A

1% water, 3% organic components, 96% inorganic component

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11
Q

What comprises the inorganic component of enamel:

A

calcium hydroxyapatite

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12
Q

What is the main protein comprising the organic component of enamel?

A

tyrosine-rich amelogenin protein (TRAP)

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13
Q

What components make up TRAP?

A

Tuftelin, Sheathlin, Enamelin, and Amelogenin

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14
Q

Exhibits thixotropic properties (the ability to flow under pressure) and comprises most of TRAP:

A

amelogenin

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15
Q

Considered one of the largest of the TRAP proteins:

A

Enamelin

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16
Q

An acidic, phosphorylated and glycosylated protein & the largest of the enamel matrix proteins.

A

Enamelin

17
Q

Enamelin is preferentially restricted to the ___ area.

A

rod area

18
Q

The phosphorylated nature and initial accumulation near the growing ends of crystals suggest that enamelin plays a role in :

A

crystal growth and nucleation

19
Q

A lengthy protein that helps to connect enamelin and dentin together

A

tuftelin

20
Q

Tuftelin appears to be restricted to the _____ in enamel tufts.

A

DEJ

21
Q

This enamel protein is thought to play a role in induction, initiation of mineralization and possible functions as a junctional protein linking enamel and dentin

A

tuftelin

22
Q

Enamel protein that is initially found throughout the rod and interrod enamel, however it is preferentially located in the rod sheaths

A

Sheathlin

23
Q

In the reciprocal induction stage, the pre-tooth bud stage ectoderm specifies the “dental nature” of the ______.

A

underlying mesenchyme (neural crest cells)

24
Q

In reciprocal induction, the neural crest cells (ectomesenchyme) then induces formation and proliferation of the:

A

dental lamina

25
Q

During reciprocal induction stage, the ___ eventually spearates into an outer and inner dental epithelium

A

dental lamina

26
Q

In reciprocal induction, the inner enamel epithelium induces differentiation of:

A

odontoblast

27
Q

During reciprocal induction, the _____ secrete the mantle layer of dentin

A

ondontoblasts

28
Q

In reciprocal induction, once the mantle layer of dentin is formed, _____ is initiated and ____ beings shortly thereafter

A

ameloblast differentiation; amelogenesis

29
Q

The gradient of cellular differentiation, matrix secretion, and mineralization during tooth development is ____ to ____ (dentition), and ___ to ____ (individual teeth)

A

anterior to posterior

coronal to apical

30
Q

List the stages of ameloblast function (5)

A
  1. morphogenic stage
  2. differentiation stage
  3. secretory stage
  4. maturation stage
  5. protective stage