Alanine Amino Transferase (ALT)

Question 1

Other name of ALT

Answer 1

Serum Glutamic-Pyruvic Transaminase

Question 2

product of ALT enzyme activity

Answer 2

Glutamatic
Pyruvic

Question 3

True or False

ALT is not liver specific

Answer 3

False (ALT is more liver specific)

Question 4

Clinical Significance of ALT

Answer 4

• Hepatic disorder (ACUTE inflammatory conditions)
• Course of Hepatitis Treatment (low ALT = effective)
• Monitors Drug Therapy (Kidney and liver is affected)
• Specific and sensitive markers for Post Transfusion Hepatitis and Occupational Toxic Exposure
• Use for screening hepatitis for blood donors
• Increased in Hepatocellular disorders

Question 5

The second substrate used for the enzymatic Assay of ALT

Answer 5

Lactate dehydrogenase

Question 6

differentiate caused of hepatic disorder; AST/ALT ratio

Answer 6

De Ritis Ratio

Question 7

Ratio < 1 ( ALT > AST)

Answer 7

Viral

Question 8

Ratio > 1 (AST > ALT)

Answer 8

Nonviral

Question 9

Color developer for ALT and AST

Answer 9

2,4 DNPH Dinitrophenylhydrazine)

Question 10

Color intensifier for AST and ALT

Answer 10

0.4 N NaOH

Question 11

Colorimetric Assay For ALT and AST

Answer 11

Reitman and Frankel