AINES

Question 1

AINES, caracteristicas

Answer 1

tx: dolor nociceptivo, neuropatico, inflamatorio
inhibicion: COX1 (GI, todas las cel), COX2 (prototrombotico)
Ac debil, >90% union a prot: -VD
acumulacion sitios inflamados, excepto: paracetamol, celecoxib
NO 2 juntos, excepto: AINE + paracetamol
EA: tinnitus, lipoacusia, insuf renal: aine + viejito + deshidratados

Question 2

AINES, farmacos

Answer 2

ketorolaco
aspirina
ibuprofeno
naproxeno
meloxicam
celecoxib
dioxicam
paracetamol
indometacina

Question 3

ketorolaco

Answer 3

+ efectivo, agresivo GI
NO >5dias
EA: renal

Question 4

aspirina

Answer 4

inhibicion irreversible
80-160mg: antiagregante, >300: analgesico
EA: Sd reye: <12, antecedentes: influenza, varicela

Question 5

ibuprofeno

Answer 5

+ seguro

Question 6

naproxeno

Answer 6

tx cefaleas, - riesgo cardiaco

Question 7

diclofenaco

Answer 7

COX2, en articulaciones inflamadas

Question 8

meloxicam

Answer 8

COX2

Question 9

celecoxib

Answer 9

COX2, NO dolor agudo, + enf cardiovasculares

Question 10

indometacina

Answer 10

+EA: cefalea, vertigo, confusion

Question 11

Dioxicam

Answer 11

COX2

Question 12

paracetamol (acetaminofen)

Answer 12

tx dolor leve-moderado
adulto max 40000mg-4gr
NO: anti inflamaotrio
EA: sd gilbert: hepatotoxicidad: -glucagon