Ageing and Immunity 14.11.23 Flashcards
1
Q
What immunological alterations occur with ageing
A
Decreased innate response (less neutrophils, less phagocytosis)
Increased inflammatory cytokines
Mixed increase + decreased adaptive response
2
Q
What is immunosenescence?
A
Gradual deterioration of the immune system
3
Q
Slide 10-14
A
4
Q
What is Senescence-Associated Secretory Phenotype (SASP)?
A
a phenotype associated with senescent cells wherein those cells secrete high levels of inflammatory cytokines, immune modulators, growth factors, and proteases.
