Advanced Microbiology Flashcards
CRP and procalcitonin are
non-specific inflammatory markers
Legionella antigen detection tests are a form of
direct detection that can be used at the point of care
HSV can be treated with
Aciclovir
VZV can be treated with
Aciclovir
Influenza can be treated with
Ostelamivir (oral)
Zanamavir (inhaled)
Hep C is an exception because it is a
RNA virus
NRTIs like AZT work by
inhibiting HIV replication
What type of infection would show normal WCC, high lymphocytes and normal neutrophils?
viral
HIV pyrimidine analogues include
Zidovudine and Lamivudine
HIV purine analogues include
Abacavir and Terbfair
Lamivudine and Terbafavir also work against
Hep B
Acyclovir and Ganciclovir are
Herpes polymerase inhibitors
An example of a hep C polymerase nucleotide inhibitors is
Sofosbuvir
NNRTIs include
Efavirenz and Nevirapine
Ritonavir is used to boost the levels of other
Polymerase inhibitors
HAART is composed of
2 NRTIs and NNRTI or
2 NRTIs and a boosted PI/integrase inhibitor
A M18V4 HIV mutation leads to resistance to
Lamivudine
peptidoglycan is a polymer of
N-acetyl muramic acid and N-acetyl glucosamine
beta-1,3-glucan is a polymer of
UDP-glucose
Antivirals that inhibit replication can be
Polymerases
NRTIs
NNRTIs
Protease inhibitors
Echinocandins, beta-lactams and glycopeptides are
cell wall synthesis inhibitors
an example of a beta-lactam with G-VE activity only is
Aztreonam, a monobactam
Tazocin increases the spectrum of what beta-lactam
piperacillin
Echinocandins end in
-‘fungin’
Aminoglycosides, MLS antibiotics, tetracyclines and omazolidinones are
protein synthesis inhibitors in bacteria
Gentamicin binds to
the 30S subunit