adrenergic-blocking: chapter 20 Flashcards
mechanism of action of adrenergic blocking drugs
interrupt stimulation of a1 receptors
4 effects of adrenergic blocking drugs
vasodilation, reduce systemic vascular resistance, reduce bp, reduce smooth muscle contaction
5 contraindications for the use of adrenergic-blocking drugs
pvd, liver or kidney disease, cad, peptic ulcer, sepsis
what is the first dose phenomenon associated with adrenergic-blocking drugs
severe and sudden drop in blood pressure after the first dose
treatment for adrenergic-blocking drug toxicity/overdose
gastric lavage, activated charcoal
2 key adrenergic blocking drugs
phentolamine, tamulosin
what is the most common use for phentoloamine
treat extravasation of iv drugs such as norepinephrine, epinephrine, diobutamine, and dopamine
why is phentolamine used to treat extravasation
increases blood flow to ischemic tissue and prevent permanent damage
which adrenergic blocking drug is used to treat bph
tamulosin
how does tamulosin have the ability to treat bph
blocks a receptors on smooth muscle in the prostate and bladder which relaxes the smooth muscle to improve urinary flow
key drug interaction of tamulosin
cause additive hypotensive effects when used alongside erectile dysfunction drugs
mechanism of action of bet blockers
block stimulation of b receptors by competing with norepinephrine and epinephrine
which receptors are targeted if the beta blocker is selective
b1
which receptors are targeted if the beta blocker is nonselective
b1 and b2
what is the effect of beta blockers on the heart (5)
reduce myocardial stimulation, reduce hr, slow conduction of the av node, prolong sa node recovery, decrease myocardial contractility
what effect does beta blockers have on the resp system
cause smooth muscle contraction and narrowing of airways
what effect do beta blockers have on blood glucose levels. how
elevation of blood glucose levels due to impaired insulin secretion
5 indications for beta blockers in terms of the cv system
angina, mi, cardiac dysrhythmia, hypertension, heart failure
why may beta blockers be given after an mi
it has cardioprotective properties by inhibiting stimulation of catecholamines
what can beta blockers be used for in terms of the eye
galucoma
5 contraindications for the use of beta blockers
acute exacerbation of heart failure, cardiogenic shock, bradycardia, pregnancy, severe pulmonary disease, raynaud’s syndrome
what drug is used to treat bradycardia due to overdose of adrenergic-blocking drugs
atrophine
what drug is used to treat hypotension due to overdose of adrenergic-blocking drugs
vasopressors
what drug is used to treat seizures due to overdose of adrenergic-blocking drugs
diazepam
