adrenergic-blocking: chapter 20 Flashcards

1
Q

mechanism of action of adrenergic blocking drugs

A

interrupt stimulation of a1 receptors

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2
Q

4 effects of adrenergic blocking drugs

A

vasodilation, reduce systemic vascular resistance, reduce bp, reduce smooth muscle contaction

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3
Q

5 contraindications for the use of adrenergic-blocking drugs

A

pvd, liver or kidney disease, cad, peptic ulcer, sepsis

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4
Q

what is the first dose phenomenon associated with adrenergic-blocking drugs

A

severe and sudden drop in blood pressure after the first dose

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5
Q

treatment for adrenergic-blocking drug toxicity/overdose

A

gastric lavage, activated charcoal

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6
Q

2 key adrenergic blocking drugs

A

phentolamine, tamulosin

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7
Q

what is the most common use for phentoloamine

A

treat extravasation of iv drugs such as norepinephrine, epinephrine, diobutamine, and dopamine

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8
Q

why is phentolamine used to treat extravasation

A

increases blood flow to ischemic tissue and prevent permanent damage

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9
Q

which adrenergic blocking drug is used to treat bph

A

tamulosin

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10
Q

how does tamulosin have the ability to treat bph

A

blocks a receptors on smooth muscle in the prostate and bladder which relaxes the smooth muscle to improve urinary flow

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11
Q

key drug interaction of tamulosin

A

cause additive hypotensive effects when used alongside erectile dysfunction drugs

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12
Q

mechanism of action of bet blockers

A

block stimulation of b receptors by competing with norepinephrine and epinephrine

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13
Q

which receptors are targeted if the beta blocker is selective

A

b1

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14
Q

which receptors are targeted if the beta blocker is nonselective

A

b1 and b2

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15
Q

what is the effect of beta blockers on the heart (5)

A

reduce myocardial stimulation, reduce hr, slow conduction of the av node, prolong sa node recovery, decrease myocardial contractility

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16
Q

what effect does beta blockers have on the resp system

A

cause smooth muscle contraction and narrowing of airways

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17
Q

what effect do beta blockers have on blood glucose levels. how

A

elevation of blood glucose levels due to impaired insulin secretion

18
Q

5 indications for beta blockers in terms of the cv system

A

angina, mi, cardiac dysrhythmia, hypertension, heart failure

19
Q

why may beta blockers be given after an mi

A

it has cardioprotective properties by inhibiting stimulation of catecholamines

20
Q

what can beta blockers be used for in terms of the eye

A

galucoma

21
Q

5 contraindications for the use of beta blockers

A

acute exacerbation of heart failure, cardiogenic shock, bradycardia, pregnancy, severe pulmonary disease, raynaud’s syndrome

22
Q

what drug is used to treat bradycardia due to overdose of adrenergic-blocking drugs

A

atrophine

23
Q

what drug is used to treat hypotension due to overdose of adrenergic-blocking drugs

A

vasopressors

24
Q

what drug is used to treat seizures due to overdose of adrenergic-blocking drugs

A

diazepam

25
Q

what is used to enhance elimination in the case of overdose of adrenergic-blocking drugs

A

hemodialysis

26
Q

what do all beta blocker drugs end in

A

-ol

27
Q

is atenolol selective or nonselective

A

selective

28
Q

what is the main indication for the use of atenolol

A

prevent future mi after one has occured

29
Q

what drug class is carvedilol (3)

A

nonselective beta blocker, a1 blocker, calcium channel blocker

30
Q

what is the main indication for carvedilol

A

heart failure

31
Q

what receptors does esmolol target

A

b1

32
Q

indication for esmolol

A

rapid temporary control of dysrhythmia

33
Q

what receptors does labetalol target

A

b and a

34
Q

indication for labetalol

A

treat severe hypertension and hypertensive emergencies

35
Q

what receptor does metoprolol target

A

b1

36
Q

indication for the use of metoprolol

A

use after an mi

37
Q

what receptor does propanolol target

A

nonselective b1 and b2 blocking

38
Q

indication for propanolol

A

treat dysrhythmia associated with cardiac glycoside intoxication

39
Q

what 2 things must be assessed before administering an adrenergic blocking drug or beta blocker

A

assess the apical pulse for 1 full min, bp

40
Q

what apical pulse and bp would indicate to the nurse to hold a beta blocker or adrenergic blocking drug

A

apical: less than 60 or above 100
bp: systolic is less than 100 or diastolic is less than 60