ADHD Flashcards

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1
Q

part of brain most involved in ADHD

A

prefrontal cortex

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2
Q

when does the prefrontal cortex finish myelination

A

25

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3
Q

Genetics and ADHD

A
  • Genetic imbalance in dopamine and noradrenergic systems

- Strong genetic influence

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4
Q

Environment and ADHD

A
  • Increased risk with prenatal smoking exposure
  • Prematurity, Brain injury, fetal alcohol, lead
  • Dietary factors do not play a role in majority of children
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5
Q

when must symptoms of ADHD be present

A

by 12 years of age

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6
Q

how many symptoms must be present to have ADHD

A

6/9

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7
Q

criteria symptoms for inattentive ADHD

A
  • careless mistakes
  • Difficulty sustaining attention
  • Does not seem to listen
  • Does not follow through on tasks
  • Not organized
  • Avoids sustained mental effort
  • Loses things
  • Is easily distracted
  • forgetful
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8
Q

criteria symtpoms for hyperactive/impulsivity ADHD

A
  • Fidgets or squirms
  • Inappropriately leaves seat
  • inappropriately runs or climbs
  • Has difficulty playing quietly
  • is “on the go”
  • Talks excessively
  • Blurts out answers
  • Has Difficultly waiting his or her turn
  • Interrupts or intrudes on others
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9
Q

time frame for ADHD

A

present for over 6 months

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10
Q

Comorbidities with ADHD?

A
  • Learning disorder (10-30%)
  • Opposition defiant disorder/Conduct disorder
  • Anxiety or mood disorder
  • Tourette’s and tic disorders
  • coordination problems
  • substance abuse
  • sleep problems
  • Triad of psychiatry
  • PANDA’s
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11
Q

What is the triad of psychiatry

A
  • ADHD
  • Tourette’s syndrome
  • OCD
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12
Q

What is PANDA’s

A

post infectious state that looks like Triad of psychiatry

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13
Q

Primary MOA of stimulants

A
  • block reuptake pump

- increases dopamine and NE

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14
Q

What action does amphetamine have that other stimulants don’t

A

-cause presynaptic release into synapse

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15
Q

Common side effects of stimulants

A
  • Decreased appetite - give with or after meals
  • Difficulty falling asleep
  • Tics
  • upset stomach . .give with food
  • Headaches
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16
Q

Less common side effects of stimulants

A
  • Moodiness or irritability
  • Overly quiet “Zombie effect”
  • Weight loss
  • small decrease in height velocity
  • Rebound symptoms as med wears off
  • Mild increase in heart rate and BP
  • Rare risk of mania or hallucinations
  • Priapism . .trazadone
17
Q

FDA concern about stimlulant use

A
  • don’t use if heart disease, arrhythmia, or FH of arrhythmia
  • EEG not needed if carciac hx is negative
18
Q

MOA of Atomoxetine (straterra)

A

-selective NE reuptake inhibitor

19
Q

Atomoxetine is useful in ADHD with what

A

anxiety or depression

20
Q

Side effects of Atomoxetine

A
  • Somnolence: can give in evening or divide dose
  • Anorexia, GI upset, weight loss - give with food , divide dose
  • Dizziness
  • Rare risk of liver disease
  • Increased risk of suicidal ideation
21
Q

What are the alpha 2 agonists used to treat ADHD

A

Clonidine and Guanfacine

22
Q

describe Clonidine and Guanfacine and how they work

A
  • useful for sleep, tics, aggression, hyperarousal
  • not as effective for inattention
  • Used as adjunctive
  • Work on POST SYNAPTIC ALPHA 2 receptor as agonist
23
Q

Side effects of The alpha 2 agonists

A
  • Sedation (especially with clonidine)
  • Dry mouth
  • depression
  • low BP
  • headache
24
Q

Withdrawal symptoms of the alpha 2 agonists if suddenly stopped

A
  • high pulse
  • BP
  • headache
  • agitation
25
Q

Treatment of ADHD with anxiety

A
  • responds to stimulants
  • May need to add SSRI
  • another option is atomexetine
26
Q

Treatment of ADHD and tics

A
  • Stimulants and clonidine

- Atomoxetine

27
Q

Treatment of ADHD and aggression

A

-Stimulant and clonidine/guanfacine