Actinic Keratosis and Squamous Cell Carcinomas

Question 1

Squamous cell carcinoma

Answer 1

Common in white/fair skin, around sun-exposed areas, increased mortality

Question 2

SCC in situ

Answer 2

Bowen’s disease, circumscribed pink patch/plaques with scale; does not invade past DEJ

Question 3

Actinic keratosis

Answer 3

Rough, scaly, thin, pink plaques; premalignant lesion

Question 4

Location of actinic keratosis

Answer 4

Sun exposed skin; head neck, extensor forearms, dorsal hands

Question 5

Features of sun damaged skin

Answer 5

Atropy, hypertrophy, telangiectasias, spotty depigmentation/hyperpigmentation, wrinkles, leathery

Question 6

Appearance of basal cell carcinoma

Answer 6

Pearly pink papule with telangiectasias

Question 7

Risk factors for BCC

Answer 7

Fair skin, UV exposure, ionizing radiation, arsenic ingestion, immune suppression

Question 8

Nodular BCC

Answer 8

Most common, pearly papule with telangiectasia

Question 9

Superficial BCC

Answer 9

Pink or translucent telangiectasia, patch or plaque

Question 10

Ulcerated BCC

Answer 10

Translucent, telangiectasia, rolled border, ulcerated, crusting over

Question 11

Pigmented BCC

Answer 11

Has globules of dark pigment

Question 12

Morpheaform BCC

Answer 12

Translucent, telangiectasia, rolled border, scarred

Question 13

Skin pigmentation dependent on

Answer 13

NOT the number of melanocytes but the number of melanosomes

Question 14

Most common skin cancer

Answer 14

Basal cell carcinoma; almost never metastasizes

Question 15

Pathology of BCC

Answer 15

Basophilic hyperchroatic cells, cells palisades, retraction from stroma

Question 16

Basal cell nevus syndrome

Answer 16

AD mutation in PTCH1 tumor suppressor gene,

Question 17

Pathology of SCC

Answer 17

Hyperchromatic, keratin pearls, extending into dermis