Abdominal: Gastric Adenocarcinoma (brief)

Question 1

who is more likely to get gastric adenocarcinoma, men or women?

Answer 1

Men are twice as likely as women, incidence increases with age (peak 50-70 years).

Question 2

what are the two major types of gastric adenocarcinoma?

Answer 2

Intestinal (type 1): with well-formed glandular structures (differentiated).

Diffuse (type 2): with poorly cohesive cells (undifferentiated) that tend to infiltrate the gastric wall, may involve any part of the stomach.

Question 3

what are risk factors for gastric adenocarcinoma?

Answer 3

• High salt diet/low fibre diet.
• Smoking.
• Male.
• Over the age of 55.
• H. Pylori. Infection.
• Family history.
• Having another type of cancer.
• Peptic stomach ulcers.
• Pernicious anaemia.
• Stomach polyps.

Question 4

what are clinical features of early stages gastric adenocarcinoma?

Answer 4

tend to be asymptomatic

Question 5

what are clinical features of advanced gastric adenocarcinoma?

Answer 5

• Epigastric pain.
• Nausea.
• Anorexia/weight loss.
• Vomiting.
• Dysphagia.
• Anaemia.
• Indigestion is a very common.

Question 6

what is a curative treatment of gastric adenocarcinoma?

Answer 6

Surgery + peri-operative chemotherapy (3 cycles of neoadjuvant and 3 cycles of adjuvant).