AB discovery 3

Question 1

What is MCR1?

Answer 1

resistance mechanism to colistin

Question 2

why is MCR1 such a problem?

Answer 2

carried on a plasmid so can be transferred between organisms

Question 3

what was colistin resistance fuled by?

Answer 3

its use in pigs which has since been banned

Question 4

colistin is also referred to as. _____ ____

Answer 4

polymyxin E

Question 5

what bacteria does colistin come from?

Answer 5

bacillus sp

Question 6

when is colistin considered for use

Answer 6

LAST LINE- when there’s carbapenem resistance as this is very hard to treat and there’s a shortage of new alternatives to treat gram negatives

Question 7

why is colistin not used much?

Answer 7

nephrotoxic

Question 8

3 things driving AB resistance

Answer 8

inappropriate use in agriculture
inappropriate use in humans
waste from manufacturers

Question 9

why does use in agriculture lead to resistance

Answer 9

AB in food chain and faeces

makes its way into water sources and the environment

Question 10

explain waste from manufacturers contribution to AB resistance?

Answer 10

environmental exposure to antibiotics- selection pressure

Question 11

ways to tackle antimicrobial resistance

Answer 11

public awareness
hygiene and sanitation improvements
reduce use in: agriculture and humans
promote development and use of vaccines