AB discovery 3 Flashcards
What is MCR1?
resistance mechanism to colistin
why is MCR1 such a problem?
carried on a plasmid so can be transferred between organisms
what was colistin resistance fuled by?
its use in pigs which has since been banned
colistin is also referred to as. _____ ____
polymyxin E
what bacteria does colistin come from?
bacillus sp
when is colistin considered for use
LAST LINE- when there’s carbapenem resistance as this is very hard to treat and there’s a shortage of new alternatives to treat gram negatives
why is colistin not used much?
nephrotoxic
3 things driving AB resistance
inappropriate use in agriculture
inappropriate use in humans
waste from manufacturers
why does use in agriculture lead to resistance
AB in food chain and faeces
makes its way into water sources and the environment
explain waste from manufacturers contribution to AB resistance?
environmental exposure to antibiotics- selection pressure
ways to tackle antimicrobial resistance
public awareness
hygiene and sanitation improvements
reduce use in: agriculture and humans
promote development and use of vaccines
