AB discovery 1

Question 1

problem with penicillin when it was first discovered?

Answer 1

low yields and difficulty purifying

Question 2

who described purification at a later date?

Answer 2

Florey and chain

Question 3

what year was penicillin mass produced

Answer 3

1945

Question 4

deifinition of a antibiotic?

Answer 4

a chemical of natural or synthetic origin which (usually at low concentrations) inhibits microorganisms of some type within a host, while not interfering with the life of that organism

Question 5

what is a AM? how is it different to a AB?

Answer 5

umbrella term- any agent which has an antagonistic effect towards a bacteria
e.g. bleach- not a ab

Question 6

what’s the Waksman platform?

Answer 6

systematic screening of environmental samples

Question 7

how were natural ABs produced large scale?

Answer 7

large scale fermentation of bacteria/ fungi

Question 8

what years was the golden era

Answer 8

1910-1960’s

Question 9

what happened to thewawsman discovery platform at the end of the golden era

Answer 9

it broke down- couldn’t find anymore natural products

Question 10

what new research directions did we have to go in (2 examples please)

Answer 10

1. modification of existing natural products

2. manufacture by pure synthetic routes