AB discovery 2 Flashcards
how did we identify bacterial targets?
genomic/ proteomic data
results for new synthetic groups were promising? TF
FALSE
bacterial cell wall is ____ charged. effect?
negative
stops hydrophilic compounds
what can happen to a AB even if it gets past the cell wall?
effluxed out
how to increase effect of beta lactams?
give with inhibitors of beta lactamases
teixobactin discovery?
isolation of eleftheria terrae
produces this
grown in soil
teixobactin activity against which bacteria?
S.pneumoniae
MRSA
M.tb
teixobactin MOA?
peptidoglycan biosynthesis inhibitor
targets lipid 2 and 3 (precursor cell wall components)
what are lipid 2 and 3 in relation to bacteria?
precursor cell wall components
has there been any resistance acquired against texiobactin?
not yet
does texiobactin have activity against gram negative bacteria? explain
no
cant get through the cell wall
what is lugdunin?
produced by staph lugdenenis- taken from the nose of a healthy adult
cyclic peptide AB
what type of AB is lugdunin?
cyclic peptide AB
lugdunin is active against which gram bacteria?
gram positive inc mesa, vre
