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AANIYA PATH > Aani Micro: Herpes > Flashcards

Aani Micro: Herpes Flashcards

1
Q

Where is VZV stored as a latent infection?

A

Dorsal Root ganglia

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2
Q

What are the symptoms of shingles?

A

Painful rash in specific dermatone

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3
Q

What is the treatment of shingles?

A 
800mg Acyclovir 5 times a day
OR
250mg Famciclovir TDS
OR 
1000mg Valacyclovir TDS
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4
Q

What is the spread of Herpes infection HSV1/2?

A

Mucocutaneous

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5
Q

What is the spread of VZV?

A

Droplet infection

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6
Q

Describe the genetic make up of Herpes?

A

double stranded DNA

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7
Q

Which Herpes strain most commonly causes herpes encephalitis?

A

HSV1

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8
Q

Which Herpes strain most commonly causes Mollaret’s Meningitis?

A

HSV2

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9
Q

What is another differential for Cold sores?

A

Could be Herpangina (hand foot and mouth in adults- caused by Coxsackie A)

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10
Q

What genital symptoms do you get from Herpes Simplex?

A

Pain
Rash
Sacral Radiculomyelitis (urinary retention)

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11
Q

What eye symptoms can you get from HSV if you are immunocompromised?

A

PORN

Progressive Outer Retinal Necrosis

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12
Q

Which trimester is associated with transmission of HSV to foetuses?

A

Third

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13
Q

What treatment do you give if a mother has HSV and is pregnant

A

TO MOTHERS. Give oral or IV Acyclovir 6weeks before EDD

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14
Q

What will you see in CSF if someone has Herpes enceph or molarett’s meningitis?

A

Raised protein

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15
Q

Treatment of Herpes Enceph/Molarett’s meningitis?

A

STAT IV Acyclovir 10mg/kg
THEN
Oral Acyclovir for 2-3 weeks

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16
Q

What are scrum pox?

A

Herpes Simplex skin lesions on the face caused by skin contact e.g. scrumming in Rugby

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17
Q

What other skin lesions can you get from Herpes Simplex?

A

Red painful finger (Whitlow)
Erythema Multiforme
Eczema Herpeticum

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18
Q

Which strain of herpes is in the Varicella Zoster vaccine?

A

Oka Strain

19
Q

Describe the skin rash in VZV?

A

Vesicles - droplet (raindrops on roses_)

20
Q

What cells will be present in VZV infection?

A

Multinucleated giant cells i.e. Tzanck Cells

21
Q

What symptoms can a baby get if they have congenital varicella syndrome?

A

Cataracts
Psychomotor Retardation
Hypoplastic limbs

22
Q

Who should you treat for VZV? and How?

A 
Adults
neonates
Immunocompromised
People with painful symptoms
People with eye-involvement

Treat with 800mg Acyclocvir PO TDS 1 week

23
Q

What are the 3 broad categories of Herpes Virus? And the viruses within them?

A

Alpha- HS1, HS2 and VZV
Beta- CMV, HH6 and HH7
Gamma- HH8 and EBV

24
Q

What do HH6 and 7 cause?

A

Roseola Infantum i.e. 6th disease i.e. Exanthum Subitum

25
Q

What can HH8 cause?

A

Castleman’s Syndrome (benign LN growth)
or
Kaposi’s Sacrcoma

26
Q

Which cells will you see in Kaposi Sarcoma?

A

Spindle Cells
AND
Kaposi Sarcoma Herpes Virus Cells (KSHV)

27
Q

What can EBV become?

A

In immunocomp when T cells cannot keep B cells in check, there is uncontrolled B cell prolif and you can get Post Transplant Lymphoprolif disease (PTLD) or Burkitt’s Lymphoma

burkitt’s
hodgkins (reed sternberg owl eye cells)
nasopharyngeal carcinoma
oral hairy leukoplakia

28
Q

What is the Tx of EBV?

A

largely supportive, avoid penicillins - can provoke rash

29
Q

What type of infection is EBV?

A

Mononucleosis

30
Q

Tx of HH8?

A

start antiretroviral therapy

31
Q

Tx of HH6/7?

A

nothing

32
Q

Which of the alpha Herpes Virus is most/least sensitive?

A

Most: HSV1
Least: VZV (high medication dose needed)

33
Q

Which cells do you get in CMV?

A

Owl Eye Inclusion bodies
Monocucleosis
Swollen large cells hence ‘megalovirus’

34
Q

What symptoms can you get in CMV if you are immunocompetent?

A

80% asymptomatic

Fever, SOB, penumonia

35
Q

What symptoms can you get in CMV if you are immunosuppressed?

A

Retinitis (haemorrhagic exudate changes)

oesophagitis

36
Q

Tx of CMV?

A

1st: ganciclovir or valganciclovir
2nd: foscarnet or cidofovir

37
Q

Investigations for CMV?

A

Blood- owl eye inclusion bodies

Paul Bunnel Ab test- clumping of sheep RBCs

38
Q

Which conditions does Paul Bunnell Test identify? (positive clumping of sheep RBC)

A

EBC and CMV

39
Q

Which cells do CMV stay latent in?

A

B Lymphocytes

40
Q

Which cells do HH6 and HH7 Stay latent in?

A

Monocytes/T cells/ epithelial cells

41
Q

Which people get Burkitt’s lumphoma? What do they look like?

A

African kids with big jaw

42
Q

Treatment of Burkitt’s Lymphoma?

A

Rituximab

43
Q

Which virus can cause Burkitt’s Lymphoma?

A

EBV

AANIYA PATH (35 decks)

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