Aani Micro: Endocarditis Flashcards

1
Q

Which organism causes acute infective endocarditis?

A

Staph Aureus

prosthetic valve = Coagulase-NEG staphylococci (staph epidermidis)

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2
Q

Which organism causes subacute infective endocarditis?

A

Strep Viridians

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3
Q

What are the differences between subacute and acute endocarditis?

A

Acute: fast
On normal heart valves
Echo shows large vegetations
Severe disease

Subacute: slow
On abnormal heart valves
Echo shows small vegetations
Mild/mod illness

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4
Q

Which organism is most likely to cause prosthetic valve bacterial endocarditis?

A

Coagulase-negative staphylococci

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5
Q

How to investigate for infective endocarditis?

A
3 x blood cultures 6 hours apart
U&Es (haematuria might show due to immune complexes)
CRP
FBC
CXR
Echo
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6
Q

How to treat prosthetic valve endocarditis?

A

Vanc + Gent + Rifamp

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7
Q

How to treat Strep Viridians?

A

Benzylpenicillin + Gent

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8
Q

How to treat regular native valve endocarditis?

A

Flucloxacillin

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9
Q

How to treat MRSA endocarditis?

A

Vancomycin + Gent + Rifamp + Fucidin

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10
Q

Which valves are commonly affected in endocarditis?

A

Mitral and Aortic

Tricuspid in IVDU

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11
Q

Which criteria is used to diagnose infective endocarditis?

A

Dukes criteria

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12
Q

Explain dukes criteria

A

You need either 2 majors, 1 major and 3 minors or 5 minors to make the diagnosis.

The major criteria are:
1. Echo vegetations seen
2. 2+ positive blood cultures
3. + serology for bartonella, coxiella or brucella
The minor criteria are:
1. Rfs e.g. IVDU/murmur
2. Fever above 38 degrees
3. Immune complex formation e.g. splinter haemorrhages
4. Vasc phenomenon (stroke/PE etc)
5. Positive echo that doesn’t show vegetations
6. 1 positive blood culture

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13
Q

What is special about the HACEK group?

A

They cause gram negative bacilli endocarditis

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14
Q

What is in the HACEK group?

A
Haemophilus Parainfluenza
Aggregatibacter/acintobacter
Cardiobacterium hominis
Eikenella Corrodens
KIngela Kingae
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15
Q

if strep bovis is found what investigation must be done

A

colonoscopy

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16
Q

which organism associated with endocarditis after Uti

A

e faecilis