Aani Haem: Leukaemia Flashcards
Which protein presence indicates a worse prognosis in CLL?
CD38 and ZAP70
Which protein presence indicates CLL?
CD5 & CD23
Which staging is used in CLL?
Binet (A,B,C)
What is it called when CLL turns into a lymphoma?
Richter’s Transformation
Which syndrome is associated with CLL?
Evan’s Syndrome
Which Leukaemia is Evan’s Syndrome associated with?
CLL
What is the management of CLL?
- Chlorambucil
- Fludarabine
- Alemtuzumab
Which cells are seen in a CLL blood film?
Smear Cells
Which M group is APL? (Acute Promyelocytic Leukaemia)
M3
M4 and M5 are which type of AML?
Acute Monocytic Leukaemia
Which Leukaemia makes you more prone to DIC?
APL (a type of AML)
Which chromosomal abnormality is seen in APL?
15;17 translocation
How to treat M3 (APL) ?
ATRA or Arsenic
Which protein are seen in AML blood film?
Auer rods
Which 2 stains can be used to identify AML?
Sudan Black B
Myeloperoxidase