Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

AANIYA PATH > Aani Immuno: Transplant & Immune therapies COPY > Flashcards

Aani Immuno: Transplant & Immune therapies COPY Flashcards

1
Q

Mnemonic for remembering the anti-proliferative immune therapies?

ie the ones that inhibit dna synthesis

A 
Aaniya Can't Make More
Azathioprine
Cyclophosphamide
Methotrexate
Mycophenolate Sodium/Mofetil
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is methotrexate used for?

A

RA
Psoriasis
Crohn’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Side effect of methotrexate?

A

Reduces folate –> Megaloblastic anaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is Mycophenolate Sodium/Mofetil used for?

A

Transplantation and vasculitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Side effect of mycophenolate mofetil?

A

Herpes virus reactivation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is azathioprine used for?

A

Transplantation, autoimmune/inflamm diseases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Contraindications to azathioprine?

A

Allopurinol use

TPMT Polymorphism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Cyclophosphamide indication?

A

Anti cancer agent
Vasculitis
Connective Tissue disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

S/E of cyclophosphamide

A

Infertility & hair loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Mnemonic for T-Cell Signalling Inhibitors

A 
ST CAT
Sirolimus
Tacrolimus
Cyclosporin
Apremilast
Tofacitinib
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Sirolimus indications? And mechanism?

A

Rejection prophylaxis

Blocks T Cell proliferation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Tacrolimus indications? And mechanism?

A

Rejection prophylaxis

Inhibits calcineurin which reduces IL2 so it reduces T cell function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Cyclosporin indications? And mechanism?

A

Rejection prophylaxis

Inhibits calcineurin which reduces IL2 so it reduces T cell function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which is the least nephrotixic of the T cell signalling inhibitor drugs?

A

Sirolimus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

S/E of Tacrolimus?

A

Nephrotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

S/E of Cyclosporin?

A

Nephrotoxicity

Gym Hypertrophy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Apremilast indication and mechanism?

A

Psoriasis & psoriatic arthritis

Inhibits PDE4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Tofacitinib mechanism? Indication?

A

JAK inhibitor

Rheumatoid arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Cell surface antigen drugs used in transplant rejection prophylaxis?

A

Basiliximab
Daclizumab
MuromonabCD3
Anti-Thymocyte Globulin (ATG)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What does Basiliximab do?

A

Inhibits CD25 via IL2 receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Indications and S/Es of Basiliximab?

A

Used in rejection prophylaxis

Can cause injection or infusion reaction

22
Q

Daclizumab mechanism? Indication ?

A

Anti- CD25 via IL2 receptor

Good for organ transplantation

23
Q

Anit Thymocyte Globulin (ATG) indications? Mechanism?

A

Allograft rejection

Inhibits migration of T Cells

24
Q

What does Natalizumab do? Indications?

A

Anti-alpha-4 integrin via VCAM1 and MadCAM1 so inhibits T Cell migration. Used in Relapsing MS and Crohns

25
Q

S/E of Natalizumab?

A

Hepatotoxic

Hyperlipidaemia

26
Q

What does Abatacept do?

A

Anti- CTRL4 Ig so inhibits T Cell migration

27
Q

What is abatacept used for?

A

Rheumatoid arthirits

28
Q

Abatacept S/E?

A

Cough

29
Q

Tocilizumab indications?

A

Castleman syndrome & RA

30
Q

Tocilizumab mechanism?

A

Anti IL6 causing low T cells, low B cells, low macrophages and low neutrophils

31
Q

Alemtuzumab indications?

A

Graft rejection
CLL
MS

32
Q

Rituximab indications?

A

Lymphoma
RA
SLE

33
Q

Alemtuzumab mechanism?

A

Anti CD52

34
Q

S/E of alemtuzumab?

A

CMV infection

35
Q

Treatment of CLL?

A

Chlorambucil
Fudarabine
Alemtuzumab

36
Q

Rituximab mechanism?

A

Anti CD20. Depletes mature B Cells

37
Q

MuromonabCD3 mechanism? Indication?

A

Anti CD3 on t cells.
Allograph rejection
(mouse Ab)

38
Q

Efalizumab mechanism?

A

Anti CD2a

Reduces T Cell migration

39
Q

Mnemonic for TNF alpha inhibitors?

A 
I'm A Cool Girl. Alpha mums, like Ada and Goli, certainly inflict pain
Infliximab
Adalimumab
Certolizumab
Golimumab
40
Q

Infliximab mechanism?

A

TNF alpha inhibitor

41
Q

Indications for TNF alpha inhibitors?

A 
RA
Psoriasis
Psoriatic arthritis
IBS
Ankylosing Spondylitis
42
Q

Ustekinumab mechanism? Indications?

A

IL12 & IL23 inhibitor

Used in psoriasis & psoriatic arthritis

43
Q

Secukinumab mechanism? Indications?

A

IL17A inhibitor

Used in psoriasis & psoriatic arthritis

44
Q

Etanercept mechanism? Indications?

A

TNF alpha Br p75IgG

Used in psoriasis & psoriatic arthritis

45
Q

Denosumab mechanism? Indications?

A

Anti-Rank
Osteoporosis
MM
Bony Mets

46
Q

S/E of denosumab

A

Avascular necrosis of the jaw

47
Q

Which drug should be prescribed in osteoporosis?

A

Denosumab

48
Q

TNFa inhibitor used in ankylosing spondylitis. It may cause lupus-like syndromes and demyelination as a side effect.

A

Etarnacept

49
Q

A 63 year old man received a renal transplant 5 years ago. He has now started to develop herpes infections and on recent investigations bone marrow suppression is seen. Which drug is responsible?

A

Mycophenolate Mofetil

50
Q

Which treatment is the most appropriate for x-linked agammaglobulinaemia?

A

Antibody replacement therapy

51
Q

A 2 month old child presents with recurrent infections, failure to thrive, persistent diarrhoea and reticular dysgenesis (low neutrophil, lymphocytes, macrophage, platelets). What is the treatment of choice?

A

Bone Marrow Transplant

52
Q

Anti-TNF alpha antibody used to treat inflammatory bowel disease?

A

Infliximab/Adalimumab/Certolizumab/Golimumab

AANIYA PATH (35 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions