AA Pharm - basic

Question 1

Class Ia

Answer 1

Na/K blockade

QRS widening
prolonged QT interval

Quinidine, Procainamide, dispyramide

Question 2

Class Ib

Answer 2

Rapid acting Na blockade

Decreases QT interval

Lidocaine, Mexiletine, Tocainide

Bind in depolarized state –> good for ischemia

Rapidly unbinds –> good for V Tach

Question 3

Class Ic

Answer 3

Long acting Na blockade

QRS widening

Flecainide, Propafenone

USE DEPENDENCE (incr toxicity at high HRs)

Question 4

Class II

Answer 4

B blockade

Decreases HR (SA, AV node)

Selective B1: Acebutolol, atenolol, bisprolol, metoprolol, esmolol

Nonselective: Nadolol, propanolol

Question 5

Class III

Answer 5

K+ channel blockade

QT prolongation

Sotalol, dofetilide, ibutilide, amiodarone

Question 6

Class IV

Answer 6

Ca channel blockade

Non-DHP: slows AV node conduction (diltiazem, verapmil)

Dihydropyridines: peripheral vasodilators (amlodipine)

Question 7

quinidine, procainamide, disopyramide

Answer 7

Class Ia

Question 8

lidocaine, mexiletine, tocainide

Answer 8

Class Ib

Question 9

flecainide, propafenone

Answer 9

Class Ic

Question 10

acebutolol, atenolol, bisprolol, metoprolol, esmolol

Answer 10

Class II (selective)

Question 11

nadolol, propanolol

Answer 11

Class II (nonselective)

Question 12

sotalol, dofetilide, ibutilide, amiodarone

Answer 12

Class III

Question 13

diltiazem, verapamil

Answer 13

Class IV (non DHP)

Question 14

amlodipine

Answer 14

Class IV (dihydropyridine)