A&P Part 3 Flashcards
responsible for carrying o2 and food to all the cells & CO2 and wastes from the cells, fluid and electrolytes for the maintenance of homeostasis, transports hormones and enzymes, transports antibodies to guard againsts infections, and controls body temperature
cardiovascular system
normal blood volume
4.73L
the process through which a cell undergoes changes in gene expression to become a more specific type of cell
Cellular differentiation or simply cell differentiation
gives rise to a class of leukocytes known as lymphocytes which include the various T cells, B cells, and natural killer cells, all of which function in immunity
Lymphoid stem cells
gives rise to all the other formed elements, including erythrocytes; megakaryocytes that produce platelets; and a myeloblast lineage that gives rise to monocytes and three forms of granular leukocytes
Myeloid stem cells
a glycoprotein hormone
prompts the production of erythrocytes
Erythroproietin
a glycoprotein hormone produced by the liver and kidneys
triggers in the development of megakaryocytes into platelets
Thrombopoietin
glycoproteins secreted by a wide variety of cells, including bone marrow, leukocytes, macrophages, fibroblasts and endothelial cells
Cytokines
are cells that have granules in the cytoplasm
granulocytes
cells that do not have granules in the cytoplasm (lymphocytes and monocytes)
Non-granulocytes
commonly known as red blood cell
primary function is to pick up inhaled oxygen from the lungs and transport it to the body’s tissues and to pick up some (about 24%) carbon dioxide waste at the tissues and transport it to the lungs for exhalation
Erythrocyte
what is an immature erythrocyte called
reticulocyte
increased retic count means that a lot of RBC’s are being _____, a decreased retic count means that RBC production is ______
produced; slower
are biconcave disks
provides a greater surface area across which gas exchanges can occur, relative to its volume
Erythrocyte
Large molecule made up of proteins and iron
Hemoglobin
Causes the body to assume a yellowish tings associated with jaundice
Bilirubin
Caused by a lack of intrinsic factor in the digestive tract
Pernicious anemia
Is required for the absorption of Vit B12, which is necessary for normal maturing of RBC’s
Intrinsic factor
Failure of bone marrow to produce enough RBCs as well as WBCs and platelets
Aplastic Anemia
Caused by an excessive destruction of RBC’s often because they ate deformed
treatment is splenectomy
Hemolytic Anemia
An inherited condition typically occurring in individuals from the Middle East, the Mediterranean, African and Southeast Asia, in which maturation of the RBCs does not proceed normally
Treatment is blood transfusions
Thalassemia
an elevated RBC count
blood disorder that causes your body to produce too many red blood cells
treatment is phlebotomy on a regular basis, every 2-3 weeks
Polycythemia
commonly known as white blood cells
major component of the body’s defenses against diseases
protects the body against invading microorganisms and body cells with mutated DNA, and they clean up debris
Leukocyte
Leukocytosis
an increase in wbc
indicates an infection or virus
Leukopenia
decrease in wbc that may indicate a virus or leukemia or chemotherapy
are rapid responders to the site of infection and are efficient phagocytes with a preference for bacteria
captures and destroys the invading bacteria or microorganisms by setting traps and ingesting them
neutrophils
are often involved in conditions that are associated with excessive inflammation, such as allergies, asthma, and autoimmune diseases
eosinophils
the least common leukocytes
releases two enzymes, histamine and heparin during allergic reactions
Basophils
granules of basophils release histamine which contributes to ____ and heparin to opposes to ____ _____
inflammation; blood clotting
are the second most common type of leukocyte
has no granules in the cytoplasm
lymphocytes
can destroy potential threats without prior exposure to a particular pathogen
Natural Killer Cells (NKC)
plays a prominent role in defending the body against specific pathogen
B cell (B lymphocytes) and T cells (T lymphocytes)
produces antibodies that destroy antigens or the pathogen associated with a particular antigen
B cells
are key fighters in what’s known as adaptive immune systems.
fights only one type of intruder
T cells
originate from myeloid stem cells
eats up waste in blood
Monocytes
referred to as thrombocytes
not a cell but rather a fragment of the cytoplasm of a cell called megakaryocyte
platelets
when the wall of a vessel is damaged
Vasoconstriction
platelets begin to clump together, becomes spiked and sticky, and bind to the exposed collagen and endothelial lining.
they simultaneously release chemicals from their granules into the plasma that further contribute to hemostasis
formation of primary platelet plug
normally is triggered by trauma
PT is the test used to evaluate this pathway
The extrinsic pathway
begins in the bloodstream and is triggered by internal damage to the wall of the vessel
PTT is the test used to evaluate this pathway
Intrinsic pathway
3 stages of clotting in the common pathway
- tissue thromboplastin + blood Ca + several blood proteins = active tissue thromboplastin
- prothrombin + thromboplastin + several blood proteins + Ca = thrombin
- fibrinogen in the presence of thrombin produces fibrin (blood clot)