9. Pulm path 1 Flashcards
wt is caplan syndrome
pneumoconiosis + RA
wc pneumocycosis is mediated by mediators such as IL-1, TNF, and cytokines released from macrophages?
Silicosis
initiail sign of IPF?
fibroblastic foci
wt causes the cellular pattern of NIP?
wt is seen histologically?
interstitial inflammation
thickening of alveolar sacks
wt is the fibrosing pattern of NIP?
fribrosis w out UIP
3 histo characteristics of IPF?
fibroblastic foci
honeycomb lung
temporal heterogenity (abrupt transition bw fibrosis and normal lung)
wt pneumoconiosis can cause emphysema?
simple CWP
3 functions of type 2 pneumocytes?
surfactant production
repair
precursor for type 1s
3 factors causing loss/suppression of cough reflex?
coma
chest pain
drugs
2 factors causing mucociliary apparatus injury?
smoking
viruses
2 factors interfering with alveolar macrophage phagocytosis?
alcohol
smoking
2 factors causing accumulation of secretions in the lung?
CF
bronchial obstruction
wt causes honeycomb lung histologically?
dense fibrosis
cystic spaces
3 late clinical signs of IPF?
hypoxemia
cyanosis
clubbing
wt is pathognomic for COP?
masson bodies (plugs)
wt factor can amplify pneumoconioses? why?
cigarette smoke due to problems w mucociliary apparatus
morphology of simple CWP?
complicated CWP?
1-2mm macules
>1cm blacked areas of fibrosis
mine worker presents 30 years with lung problem, diagnosis?
silicosis
2 forms of silicosis?
wc is worse?
crystalline (worse)
amorphous
hw does silica cause silicosis?
silica causes release of mediators from macrophages (IL-1, TNF)
wt does silicosis increase susceptibility to?
TB
most common malignancy associated w asbestos? other?
bronchochenic carcinoma
mesotheliomas
lung condition with ferruginous bodies? appearance?
asbestos
dumbells
2 lung conditions with honeycombing?
IPF
asbestos
wt color are asbestos bodies? wt surrounds them?
brown
iron
pulm condition with masson bodies?
COP
