9. Pulm path 1

Question 1

wt is caplan syndrome

Answer 1

pneumoconiosis + RA

Question 2

wc pneumocycosis is mediated by mediators such as IL-1, TNF, and cytokines released from macrophages?

Answer 2

Silicosis

Question 3

initiail sign of IPF?

Answer 3

fibroblastic foci

Question 4

wt causes the cellular pattern of NIP?

wt is seen histologically?

Answer 4

interstitial inflammation

thickening of alveolar sacks

Question 5

wt is the fibrosing pattern of NIP?

Answer 5

fribrosis w out UIP

Question 6

3 histo characteristics of IPF?

Answer 6

fibroblastic foci
honeycomb lung
temporal heterogenity (abrupt transition bw fibrosis and normal lung)

Question 7

wt pneumoconiosis can cause emphysema?

Answer 7

simple CWP

Question 8

3 functions of type 2 pneumocytes?

Answer 8

surfactant production
repair
precursor for type 1s

Question 9

3 factors causing loss/suppression of cough reflex?

Answer 9

coma
chest pain
drugs

Question 10

2 factors causing mucociliary apparatus injury?

Answer 10

smoking

viruses

Question 11

2 factors interfering with alveolar macrophage phagocytosis?

Answer 11

alcohol

smoking

Question 12

2 factors causing accumulation of secretions in the lung?

Answer 12

CF

bronchial obstruction

Question 13

wt causes honeycomb lung histologically?

Answer 13

dense fibrosis

cystic spaces

Question 14

3 late clinical signs of IPF?

Answer 14

hypoxemia
cyanosis
clubbing

Question 15

wt is pathognomic for COP?

Answer 15

masson bodies (plugs)

Question 16

wt factor can amplify pneumoconioses? why?

Answer 16

cigarette smoke due to problems w mucociliary apparatus

Question 17

morphology of simple CWP?

complicated CWP?

Answer 17

1-2mm macules

>1cm blacked areas of fibrosis

Question 18

mine worker presents 30 years with lung problem, diagnosis?

Answer 18

silicosis

Question 19

2 forms of silicosis?

wc is worse?

Answer 19

crystalline (worse)

amorphous

Question 20

hw does silica cause silicosis?

Answer 20

silica causes release of mediators from macrophages (IL-1, TNF)

Question 21

wt does silicosis increase susceptibility to?

Answer 21

TB

Question 22

most common malignancy associated w asbestos? other?

Answer 22

bronchochenic carcinoma

mesotheliomas

Question 23

lung condition with ferruginous bodies? appearance?

Answer 23

asbestos

dumbells

Question 24

2 lung conditions with honeycombing?

Answer 24

IPF

asbestos

Question 25

wt color are asbestos bodies? wt surrounds them?

Answer 25

brown

iron

Question 26

pulm condition with masson bodies?

Answer 26

COP