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DT 3 Q2 > 10. Anti TB drugs > Flashcards

10. Anti TB drugs Flashcards

1
Q

drugs used in first 2 months of TB? last 4 months?

A

RIPE or RIPS + B6
(rifampin, isoniazid, pyrazinamide, ethambutol)

RI 4 mo

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2
Q

3 AEs of rifampin?

A

GI
activates CYP450
orange body fluids

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3
Q

2 AEs of isoniazid?

A

neuropathy

neurotoxicity

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4
Q

2 AEs of pyrazinamide?

A

GI

hyperuricemia (goat)

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5
Q

Ae of Ethambutol?

A

optic neuritis

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6
Q

wt are multidrug resistant TB resistant to?

A

Isoniazid and Rifampin

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7
Q

wt are extensive drug resistant TB resistant to?

A

Isoniazid, Rifampin, FQN, one injectable

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8
Q

wt AE of TB regimen does vitamin B6 help w? drug?

A

neurotoxicity

isoniazid

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9
Q

wc TB drugs induces autometabolism?

A

rifampin

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10
Q

MOA of rifampin?

A

inhibits RNA polymerase

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11
Q

MOA of isoniazid?

A

inhibits mycolic acid formation

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12
Q

drug dependent on slow/fast acetylation?

A

isoniazid

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13
Q

when should streptomycin be used instead of ethambutol?

A

children < 5

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14
Q

2 AEs of streptomycin?

A

impaired 8th cranial nerve (vertigo)

pain at injection site

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15
Q

2 uses for Rifabutin?

AE?

A

intolerance to rifampin

MAC

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16
Q

when should rifapentine be used? contraindicatin?

A

non-cavitary pulmonary TB

HIV

17
Q

drug regimen for M leprae?

how long?

A

DR C
Dapsone
Rifampin
Clofazimine

2-5 years

18
Q

Drug regimen for MAC? wt can be added?

A

Clarithromycin (azithromycin)
Ethambutol

clofazamine, rifampin, rifabutin

19
Q

4 symptoms of MAC?

when does it usually occur?

A

Fever
night sweats
weight loss
anemia

advanced HIV (CD4 <100)

20
Q

when should prophylaxis for MAC be used?

drugs?

A 
Azithromycin
or 
Clarithromycin
or 
Rifabutin (if others not tolerated)
21
Q

wt is the disseminated form of leprosy?

localized?

A

lepromatous

tuberculoid

DT 3 Q2 (24 decks)

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