10. Anti TB drugs Flashcards
drugs used in first 2 months of TB? last 4 months?
RIPE or RIPS + B6
(rifampin, isoniazid, pyrazinamide, ethambutol)
RI 4 mo
3 AEs of rifampin?
GI
activates CYP450
orange body fluids
2 AEs of isoniazid?
neuropathy
neurotoxicity
2 AEs of pyrazinamide?
GI
hyperuricemia (goat)
Ae of Ethambutol?
optic neuritis
wt are multidrug resistant TB resistant to?
Isoniazid and Rifampin
wt are extensive drug resistant TB resistant to?
Isoniazid, Rifampin, FQN, one injectable
wt AE of TB regimen does vitamin B6 help w? drug?
neurotoxicity
isoniazid
wc TB drugs induces autometabolism?
rifampin
MOA of rifampin?
inhibits RNA polymerase
MOA of isoniazid?
inhibits mycolic acid formation
drug dependent on slow/fast acetylation?
isoniazid
when should streptomycin be used instead of ethambutol?
children < 5
2 AEs of streptomycin?
impaired 8th cranial nerve (vertigo)
pain at injection site
2 uses for Rifabutin?
AE?
intolerance to rifampin
MAC
when should rifapentine be used? contraindicatin?
non-cavitary pulmonary TB
HIV
drug regimen for M leprae?
how long?
DR C
Dapsone
Rifampin
Clofazimine
2-5 years
Drug regimen for MAC? wt can be added?
Clarithromycin (azithromycin)
Ethambutol
clofazamine, rifampin, rifabutin
4 symptoms of MAC?
when does it usually occur?
Fever
night sweats
weight loss
anemia
advanced HIV (CD4 <100)
when should prophylaxis for MAC be used?
drugs?
Azithromycin or Clarithromycin or Rifabutin (if others not tolerated)
wt is the disseminated form of leprosy?
localized?
lepromatous
tuberculoid
