21. Lung Tumors

Question 1

cells lining bronchial epithelium?

Answer 1

pseudostratified ciliated columnar

Question 2

cells in pleura?

Answer 2

mesothelial cells

Question 3

precursor lesion for squamous cell carcinoma? how can you tell?

Answer 3

carcinoma in situ

intact basement membrane

Question 4

2 precursor lesions for adenocarcinoma? size? another name?

Answer 4

adenocarcinoma in situ (bronchioloalveolar carcinoma)
<3 cm

microinvasive adenocarcinoma
= 5 mm invasion

Question 5

precursor lesion for small cell carcinoma?

Answer 5

neuroendocrine cell hyperplasia

proliferation of benign neuroendocrine cells

Question 6

lung cancer w hypercalcemia?

why?

Answer 6

squamous CC

PTHrP

Question 7

characteristics well differentiated of Squamous CC?

Answer 7

keratin pearls

intercellular bridges

Question 8

hw to diagnose poorly differentiated squamous CC?

Answer 8

IHC for CK5/6 and P63

Question 9

tumor with lepidic growth pattern?

Answer 9

adenocarcinoma in situ

Question 10

IHC stain for adenocarcinoma?

Answer 10

TTF-1

Question 11

is mucinous or non-mucious adenocarcinoma in situ worse?

cells?

Answer 11

mucinous

columnar

Question 12

mutation in adenocarcinoma?

Answer 12

EGFR

Question 13

3 markers for small cell carcinoma?

Answer 13

CD57
synaptophysin
chromogranin

Question 14

features of typical carcinoid tumor?

atypical?

Answer 14

<3cm
typical - <2 mitotic figures

atypical <10 mitotic figures

Question 15

4 most common sites lung cancer metastasizes? in order

Answer 15

Adrenal
liver
brain
bone

Question 16

risk factor for mesothelioma?

Answer 16

asbestos

Question 17

most common cause of mesothelioma?

Answer 17

idiopathic

Question 18

IHC for mesothelioma?

Answer 18

calretnin

Question 19

lung tumor associated w lambert eaton syndrome?
cause?
symptoms?

Answer 19

small cc

autoantibodies to Ca channels

proximal weakness

Question 20

hw much invasion defines adenocarcinoma?

Answer 20

5mm

Question 21

tx for most lung tumors? wc needs radiation?

Answer 21

surgery

Small CC

Question 22

peripheral mass of lungs <4cm? well circumscribed and solitary
histo?

Answer 22

hamartoma

cartilage

Question 23

lung tumor in visceral pleura?

Answer 23

solitary fibrous tumor

Question 24

cells in sarcomatiod mesothelioma?

epitheloid?

Answer 24

spindle cells, fascicles

polyhedral cells

Question 25

3 symptoms of superior vena cava syndrome?

Answer 25

venous congestion
dusky head
arm edema

Question 26

cause of horners syndrome?

symptoms?

Answer 26

compression of superior cervical ganglion

ptosis, miosis and anhidrosis on same side