21. Lung Tumors Flashcards
cells lining bronchial epithelium?
pseudostratified ciliated columnar
cells in pleura?
mesothelial cells
precursor lesion for squamous cell carcinoma? how can you tell?
carcinoma in situ
intact basement membrane
2 precursor lesions for adenocarcinoma? size? another name?
adenocarcinoma in situ (bronchioloalveolar carcinoma)
<3 cm
microinvasive adenocarcinoma
= 5 mm invasion
precursor lesion for small cell carcinoma?
neuroendocrine cell hyperplasia
proliferation of benign neuroendocrine cells
lung cancer w hypercalcemia?
why?
squamous CC
PTHrP
characteristics well differentiated of Squamous CC?
keratin pearls
intercellular bridges
hw to diagnose poorly differentiated squamous CC?
IHC for CK5/6 and P63
tumor with lepidic growth pattern?
adenocarcinoma in situ
IHC stain for adenocarcinoma?
TTF-1
is mucinous or non-mucious adenocarcinoma in situ worse?
cells?
mucinous
columnar
mutation in adenocarcinoma?
EGFR
3 markers for small cell carcinoma?
CD57
synaptophysin
chromogranin
features of typical carcinoid tumor?
atypical?
<3cm
typical - <2 mitotic figures
atypical <10 mitotic figures
4 most common sites lung cancer metastasizes? in order
Adrenal
liver
brain
bone
risk factor for mesothelioma?
asbestos
most common cause of mesothelioma?
idiopathic
IHC for mesothelioma?
calretnin
lung tumor associated w lambert eaton syndrome?
cause?
symptoms?
small cc
autoantibodies to Ca channels
proximal weakness
hw much invasion defines adenocarcinoma?
5mm
tx for most lung tumors? wc needs radiation?
surgery
Small CC
peripheral mass of lungs <4cm? well circumscribed and solitary
histo?
hamartoma
cartilage
lung tumor in visceral pleura?
solitary fibrous tumor
cells in sarcomatiod mesothelioma?
epitheloid?
spindle cells, fascicles
polyhedral cells
3 symptoms of superior vena cava syndrome?
venous congestion
dusky head
arm edema
cause of horners syndrome?
symptoms?
compression of superior cervical ganglion
ptosis, miosis and anhidrosis on same side
