18. Embryo lung Flashcards
wt stage of lung development do 5 lobes form? other things that forms?
embryonic
pulmonary arteries
wt stage consissts of lots of branching and formation of temrinal bronchioles?
wt else develops?
pseudoglandular
mucus glands
wt stage does sufactant production begin?
wt else happens?
canalicular
endothelium thins –> gas exchange
wt stage do type II pneuomocytes mature?
saccular
hw does diabetes affect lung development?
dec surfactant production
saccular stage
hw do glucocorticoids affect lung development?
name 1?
inc sufactant production
dec alveolar division and bronchial length
betamethasone
how does reduced VEGF affect alveolar?
inc size
#1 phospholipid in surfactant? 2 other components?
DPPC
protein
cholesterol
Most abundant surfactant protein?
function?
SP A
opsonization of bact and fungi
MOA of SP B?
result of deficiency?
fusogenic – enhances spread and stability of surfactant monolayer
RDS and death
MOA of surfactant C?
2 complications of deficiency?
inheritance pattern?
hydrophobic – recruit phospholipids to lipid bilayer
interstitial pneumonitis, emphysema
AD
MOA of SP D?
innate immunity for bact, fungi, virus
wc surfactant is activated by SP B?
SP C
wt week does surfactant start to increase a lot?
24 wk
3 things increasing surfactant secretion?
Glucocorticoids (stress)
estrogen
thyroid hormone
4 conditions using up surfactant?
aspiration
meconium
swallowed blood
pneumonia
retinoic acid (vit A) effect on lung development
inc alverolarization
dec BPD
testosterone affect on lung development?
slows lung development
cause of transient tachpnea of newborn?
physiologic cause?
4 associations?
tx?
fialure of fetal lung fluid reabsorption
failure of Na Channel reversal
Males
C-section
umbilical cord prolapse
depressed new=born (sedation)
O2 nasal CPAP
cause of RDS?
pysiocogic cause?
4 associations?
tx?
surfactant deficiency
SD -> alveolar colapse -> protein accumulation -> hyaline formaiton
prematurity
multiple gestation
diabetic mother
PDA
surfactant, NCPAP
4 possible causes of congenital pneumonia?
4 associations?
tx?
E coli, GBS, blood, meconium
maternal fever
uterine tenderness
foul smelling amniotic fluid
membrane ruptures
antibiotics, NCPAP
4 risk factors for spontaneous pneumothorax?
tx?
difficult deliveries
large gestational age
PP ventilation
CT diseases
chest tube (avoid PPV)
cause of congenital diaphragmatic hernia?
X ray appearance?
cause of mortality?
initial therapy?
cure?
abnormal diaphragm formaiton
bowels on left side
pulmonary hypoplasia
mechanical ventilation
repogle to LIS
surgery
newborn disease associated w sedation?
TTN
xray appearance in respiratory distress syndrome of the newborn?
frosted mug
2 things that happen in alveolar stage?
inc epithelial cells
changes in pulmonary vasculature
