11. Pulm path 2

Question 1

wc pulmonary disease is a disease of exclusion?

wt has a high diagnostic yield?

Answer 1

sarcoidosis

bronchoscopic biopsies

Question 2

3 characteristics of sarcoidosis?

pt population seen in?

Answer 2

high CD4
non-caeseating granuloma
hilar lymph involvement

you african american women or southeast

Question 3

4 histo characteristics of sarcoidosis?

Answer 3

schaumann bodies
asteroid bodies
langhans giant cell
epitheliod cells

Question 4

cause of hypersensitivity pneumonitis?

2 patients seen in?

Answer 4

immune response to inhaled antigen

farmers, pigeon people

Question 5

type of hypersensitivity in hypersensitivity pneumonitis?

Answer 5

type 3 and 4

Question 6

3 morphologic characteristics of HSP

Answer 6

fibrosis
honeycoming
noncaseating granulomas

Question 7

4 disease categories causing pulmonary eosinophilia?

Answer 7

acute E pneumonia

simply pulmonary E (loeffler syndromE)
- sulfa drugs and food

secondary pulmonary eosinophilia
- parasite bacteria, fungal

idiopathic pulmonary eosiophilia

Question 8

2 smoking related interstiital diseases?

Answer 8

Desquamative interstitial pneumonitis

respiratory bronchiolitis associated interstitial lung disease

Question 9

wt is seen with DIP

Answer 9

pigmented “smokers” macrophages

Question 10

wt is seen in RBAILD?

Answer 10

pigmented macrophages, chronic inflammation, fibrosis

Question 11

cause of acquired pulmonary alveolar proteinosis?

hw to tx?

Answer 11

GM-CSF antibody

bronchoalveolar lavage

Question 12

2 markers positive in pulmonary langerhans cell histiocytosis?
2 cells seen?

Answer 12

S100
CD1a

langhern cells and immature dendritic cells

Question 13

mutation causing surfactant dysfuction disorders?

Answer 13

ATP-binding cassette protein member 3

Question 14

pulmonary condition that is fatal in neonates?

Answer 14

acquired pulmonary alveolar proteinosis