12. Pulm Pharm Flashcards
wt % of inhaled drugs reach lower airways?
10-20%
1st line tx to reverse astham/bronchospasm?
2 drug names?
AEs?
selective B2 agonist
albuterol, levabuterol
tremor, restlessness, tachypnea, hypokalemia
short acting B agonist if 1st line not working?
MOA?
use?
AEs?
epinephrine
a1/2, b1/2 agonsit
asthma/bronchospasm
palpitation, pale, sweating, tremor
wt does overuse of b2 agonist indicate? wt is needed?
worsening asthma
better anti-inflammatory
prophylaxis tx for asthma and COPD?
suffix?
wt must be administered aswell?
AE?
LABA
-terol
corticosteroids
increase risk of asthma related deaths
2 muscaric receptor antagonists?
use?
AEs?
ipratopium, tiotropium
COPD prophylaxis
bitter taste, dry mouth, glaucoma etc.
MOA of theophylline?
metabolism?
Toxicity?
inhibit PDE
CYP450
does dependent -arrhythmias, seizure
wc airway drug may require weeks to become fully affected? name 1
use?
synergism?
AEs?
Corticosteroids beclomethasone asthama upregulate B2 receptor local adverse effects - dysphonioa, cough, candidiasis
suffix for LK receptor antagonists?
when to use?
AE?
-lukast
if pts cannot tolerate corticosteroids (kids)
hepatotoxicity
name of 5-lipoxygenase inhiitor?
Zileuton
MOA of omalizumab?
AE?
use?
inhibits IgE binding on mast cells
anaphylaxis
severe asthma not controlled by steroids
MOA of alpha-1-proteinase inhibitors?
reduce elastase
cough drug that can have hallucinaiton?
MOA?
dextromethorphan
NMDA receptor
wt class of drug is N-acetylcysteine?
MOA?
4 indications?
mucolytic
sulfhydryl gorup lowers viscosity
COPD, acetaminophen OD, CF, Chronic respiratory disease
MOA of Dornase Alpha?
use?
AE?
DNase that reduces viscosity by breaking extracellular DNA molecules
CF
Dyspnea
asthmatic kid comes in, unable to tolerate corticosteroids, wt to try?
LK inhibitor
drug for severe asthma not controlled by corticosteroids?
omalizumab
4 indications for antihistamines?
rhinitis, sleep aid, urticaria, motion sickness
indication for adrenergic agonists?
a1 agonist drug w partial a2?
a1 agonist?
a dn b agonist?
4 AEs?
decongestent
oxymetazoline
phenylphrine
pseudoephedrine
rebound congestion
HTN
ischemia
angina
prophylactic drugs for COPD?
Ipratropium
tiotropium
respiratory drug metabolize by CYP450?
Throphylline
respiratory drug w AEs of dysphonia, cough and candidiasis?
Corticosteroids
respiratory drug w increased risk of asthma related death?
LABA
