12. Pulm Pharm

Question 1

wt % of inhaled drugs reach lower airways?

Answer 1

10-20%

Question 2

1st line tx to reverse astham/bronchospasm?
2 drug names?
AEs?

Answer 2

selective B2 agonist
albuterol, levabuterol
tremor, restlessness, tachypnea, hypokalemia

Question 3

short acting B agonist if 1st line not working?
MOA?
use?
AEs?

Answer 3

epinephrine
a1/2, b1/2 agonsit
asthma/bronchospasm
palpitation, pale, sweating, tremor

Question 4

wt does overuse of b2 agonist indicate? wt is needed?

Answer 4

worsening asthma

better anti-inflammatory

Question 5

prophylaxis tx for asthma and COPD?
suffix?
wt must be administered aswell?
AE?

Answer 5

LABA
-terol
corticosteroids
increase risk of asthma related deaths

Question 6

2 muscaric receptor antagonists?
use?
AEs?

Answer 6

ipratopium, tiotropium
COPD prophylaxis
bitter taste, dry mouth, glaucoma etc.

Question 7

MOA of theophylline?
metabolism?
Toxicity?

Answer 7

inhibit PDE
CYP450
does dependent -arrhythmias, seizure

Question 8

wc airway drug may require weeks to become fully affected? name 1
use?
synergism?
AEs?

Answer 8

Corticosteroids
beclomethasone
asthama
upregulate B2 receptor
local adverse effects - dysphonioa, cough, candidiasis

Question 9

suffix for LK receptor antagonists?
when to use?
AE?

Answer 9

-lukast
if pts cannot tolerate corticosteroids (kids)
hepatotoxicity

Question 10

name of 5-lipoxygenase inhiitor?

Answer 10

Zileuton

Question 11

MOA of omalizumab?
AE?
use?

Answer 11

inhibits IgE binding on mast cells
anaphylaxis
severe asthma not controlled by steroids

Question 12

MOA of alpha-1-proteinase inhibitors?

Answer 12

reduce elastase

Question 13

cough drug that can have hallucinaiton?

MOA?

Answer 13

dextromethorphan

NMDA receptor

Question 14

wt class of drug is N-acetylcysteine?
MOA?
4 indications?

Answer 14

mucolytic
sulfhydryl gorup lowers viscosity
COPD, acetaminophen OD, CF, Chronic respiratory disease

Question 15

MOA of Dornase Alpha?
use?
AE?

Answer 15

DNase that reduces viscosity by breaking extracellular DNA molecules
CF
Dyspnea

Question 16

asthmatic kid comes in, unable to tolerate corticosteroids, wt to try?

Answer 16

LK inhibitor

Question 17

drug for severe asthma not controlled by corticosteroids?

Answer 17

omalizumab

Question 18

4 indications for antihistamines?

Answer 18

rhinitis, sleep aid, urticaria, motion sickness

Question 19

indication for adrenergic agonists?
a1 agonist drug w partial a2?
a1 agonist?
a dn b agonist?

4 AEs?

Answer 19

decongestent
oxymetazoline
phenylphrine
pseudoephedrine

rebound congestion
HTN
ischemia
angina

Question 20

prophylactic drugs for COPD?

Answer 20

Ipratropium

tiotropium

Question 21

respiratory drug metabolize by CYP450?

Answer 21

Throphylline

Question 22

respiratory drug w AEs of dysphonia, cough and candidiasis?

Answer 22

Corticosteroids

Question 23

respiratory drug w increased risk of asthma related death?

Answer 23

LABA