13. Fenger Flashcards
structure of paramyxoviridae?
- SS RNA, nonsegmented
helical + envelope
RNA-dependent RNA polymerase
pt presents w barking cough, name of cough?
virus causing? subtypes?
Parainfluenza (paramyxovirus)
Croup, ARD
most important Ig for paramyxovirus immunity?
IgA
1 cause of Lower RT infeciton in infants?
Pneumovirus/ RSV
tx for RSV?
palivizumab
function of F glycoproteins?
fusion and can make giant cells/syncytia/polykaryocytes
funciton of H?
attachment
function of N?
budding
glycoproteins in parmyxovirus?
H, N and F
glycoproteinsin morbilla virus?
H and F
glycoproteins in pneumovirus?
F
infection timeline for paramyxoviriday?
RSC, Parainfluenza 3, 1, 2, 4
wc orthomyxoviridae protein is responsible for antigen shift?
H
wt is contained in trivalent flu vaccine?
Type A
Type A
Type B
wt is contained in quadravalent flu vaccine?
who would it be given to?
2 Type A
2 Type B
elderly or immune compromised
MOA of amantadine and rimantadine?
inhibit uncoating
MOA of Zanamivir and oseltamivir?
inhibits neuroamidase
MOA of ribavirin?
inhibits RNA synthesis
is the intranasal vaccine recomended?
NO
virus associated with Reyes syndrome and Guillan Barre?
Type B H flu
wt protein in H flu lowers mucus viscosity?
neuroamidase
major cause of the common cold? hw many immunotypes?
Rhinovirus
100
wt protein could be targeted for a universal vaccine?
nucleocapsid protein
structure of picornavirus?
+ ss RNA non segmented icosahedral
which echovirus can cause respiratory illness?
pts it is severe?
D68
kids w asthma
conditions caused by type 1 parainfluenza?
Croup, ARD, colds, pharyngitis, coryza, pharyngitis
conditions caused by typee 2 parainfluenza?
croup
3 conditions caused by type 3 and 4 parainfluenza virus?
ARD, bronchitis, pneumonia
4 reasons vaccine is impractical for rhinovirus?
cant grow in culture
short immunity, IgA
many serotypes
in individual geographic location
wt is unique about coronaviridae?
peplomers due to two glycoproteins in envelope
virus causing SARS? why?
other thing it causes?
Coronavirus
binds angiotensin-converting enzyme 2 on epithelial cells (ACE2)
bronchitis in adults
wt prevented spread of SARS-CoV?
quarantine
wc virus can induce latent respiratory infections?
adenovirus
where does adenovirus replicate?
nucleus
wt is adenovirus capsid composed of?
252 hexons
12 pentons
2 adenovirus types that cause acute respiratory disease in children and military recruits?
type 4 and 7
receptor and co receptor for coronavirus?
metalloprotease
N-acetyl neuramic acid
