8D - Immunotherapy

Question 1

immunotherapy

Answer 1

Medical interventions that treat disease by modulating the immune system, typically by either amplifying or reducing an immune response.

Question 2

chimeric

Answer 2

An organism or cell containing genetic material from another organism or cell.

Question 3

monoclonal antibodies (mAbs)

Answer 3

Identical laboratory-made antibodies produced by plasma cell clones.

Question 4

cancer

Answer 4

A disease caused by the uncontrolled replication of cells with the ability to migrate to other parts of the body.

Question 5

myeloma cells

Answer 5

Rapidly-dividing cancerous plasma cells which are fused with extracted B cells from mice to produce hybridomas.

Question 6

hybridoma

Answer 6

The product of the fusion between a mouse’s extracted plasma cell and a myeloma cell.

Question 7

naked monoclonal antibodies

Answer 7

Monoclonal antibodies that do not have any other molecules attached to them.

Question 8

conjugated monoclonal antibodies

Answer 8

Monoclonal antibodies with other molecules (eg. chemotherapy drugs or radioisotopes) attached to them.

Question 9

autoantibodies

Answer 9

Antibodies directed against an organism’s own tissues.

Question 10

autoreactive

Answer 10

A cell that recognises a self-tissue or self-antigen as non-self.

Question 11

immunosuppression

Answer 11

A reduction in the ability of the immune system to generate an immune response.

Question 12

immune deficiency

Answer 12

A state in which the immune system is no longer able to protect the body against infection or disease. AKA immunodeficiency.