8.1 Biofilms and abscesses Flashcards
What is a biofilm
A structured community of bacterial cells enclosed in a self produced polymetric matrix and adherent to an inert or living surace
What are the steps in biofilm formation?
Reversible absorption Irreversible attachment Growth and division Exopolymer production and biofilm formation Attachment of other organisms to biofilm
What is attracted to already damaged valves and what causes damage itself
Streptococcus is attracted to already damaged cells and Staphylococcus can damage the valves itself
What questions do you need to think about when an infectio does not respond?
Is it an infection? Is there pus that needs draining? Is there a blockage? Is there a hole? is there a foreign body? Is the patient on the right antibiotic? Is the patient on the right dose? Is the patient compliant?
What is the treatment for acute infection of prosthetic joint?
Washout and debridement
IV antibiotics 2 weeks
Oral antibiotics 2 weeks
Oral antibiotics against biofilms 3-6 months
What is the treatment for chronic infection of prosthetic joint?
Complete removal, IV antibiotics and re-implantation OR long term suppressive antibiotics
What is the mechanism for abscess formation?
Organisms deposited in sterile site
Massive influx of neutrophils
Degranulation of neutrophils destroys tissue forming pus
Organisms grow and generate an anaerobic environment within abscess
What are the common organisms of intra-abdominal abscesses?
E.Coli
Bacteroides fragilis
Streptococcus
Enterococcus
What organism is associated with live abscess?
Streptococcus Milleri
What bacteria should you consider when someone has been travelling?
Eantamoeba histolytica
