7- Emerging infectious disease 2 Flashcards
family of zika virus
flaviviridae
when was zika virus first identified
from sentinel monkeys for yellow fever
transmission of zika virus
aedes aegypti, aeded albopictus
cycles of biting for aedes bugs with zika
sylvanic cycle
sub urban, urban cycle
vertical transmission and sexual transmission of zika to fetuses causes
fetuses have cerebral abnormalitis (microcephaly), is found in semen
zika virus is asymptomatic in the majority of infected people
true
frequent manifestations of zika
fever, rash, arthralgia, conjunctivitis
tx of zika
is usually self limiting, resolves spontaneously after 3-7 days, but arthralgia can persist for 1 month
there can also be post infection asthenia
dx of zika
rRT-PCR in serum, urine, blood
IgM IgG
genus of west nile virus
flavivirus
west nile causes what brain deformity
encephalitis
T/F west nile virus causes both sporadic infection and outbreaks that can be associated with severe neurological disease
T
what transmits west nile virus
mosquitoes of Culex species
- culex pipiens pipiens (nothern house mosquito) is a maintenance vector in north US and canada
- culex pipiens quinquefasciatus (southern house mosquitoes) are for south US
- culex tarsalis is for west US and canada
T/F birds develop prolonged high levels of viremia and serve as amplifying hosts for west nile virus, and they often remain asymptomatic
T
T/F west nile virus has no symptoms in most people
T
characteristics of neuroinvasive disease for west nile virus
- clinical manifestation of meningitis were similar to other menningitis
- encephalitis can be mild self limiting confusion to severe encephalopathy, coma and death
- can also cause acute flaccid paralysis syndrome
DX of west nile virus
serology IgM and IgG serum and CSF
- PCR based assay serum, CSF, urine
tx for west nile virus
no vaccine, no specific antiviral treatments exist
MERS causes
severe atypical pneumonia
MERS vs SARS
both coronavirusis
MERS has GI symptoms, SARS doesnt
