6.15 Embryology of the Ear and Eye Flashcards
the 3 embryonic sources of the eye?
surface ectoderm, neuroectoderm, mesenchyme (mesoderm/neural crest cells)
external eye contains?
sclera and cornea
middle eye contains?
vascular, choroid, ciliary body and iris
inner eye contains?
retina
3 compartments of the eye?
anterior, posterior, and vitreous
pair of lateral grooves which evaginate from the developing forebrain (eye fields in diencephalon, PAX6) and form the optic vesicles
optic sulci (grooves)
induced by mesenchyme adjacent to developing brain, to become cup by lens placode, to inner neural and outer pigment/vascular layer
optic vesicles
the renamed optic vesicle once the surface ectoderm has induced invagination
optic cup
groove on the ventral surface of the optic stalk, contains hyaloid artery to developing lens
choroid fissure
within choroid fissure, supplies the lens with blood during development, degenerates leaving central artery and vein of retina
hyaloid vessels
failure of closure of choroidal fissure, PAX 2 mutations, keyhole
coloboma
clouding of the lens, galactosemia, rubella during pregnancy
cataracts
surface ectoderm by optic vesicle induction, induces optic vesicle to become optic cup
placode
separation from inner surface epithelium and formation of lumen
lens vesicle
posterior wall cells elongate, primary fibers, secondary fibers fill central core later
lens fibers
separates anterior and posterior chambers during development only
pupillary membrane
failure to degenerate before birth, surgery or dries up
persisten pupillary membrane
outer fibrous layer, continuous with the substantia propria of the cornea and formed from mesenchyme surrounding optic cup
eye development
eyelids develop from?
surface ectoderm
stromal layer of cornea?
susbtantia propria
mesothelium of anterior chamber is derived from?
mesoderm
epithelium of cornea and conjunctiva formed from
surface ectoderm
develops from walls of optic cup which are continuous with the wall of the developing brain
retina
this part of the retina forms from the thinner, outer layer of the optic cup
pigment epithelium
the part of the retina forms from the inner, thicker layer of the optic cup under the influence of the lens
neuroepithelium
separation of pigment layer from neuroepithelial layer
detached retina
nerve fibers grow from the ganglion cells of the retina through the optic stalk to reach the brain, myelination continues after birth
optic nerve
pupil muscles grow from neuroectoderm, sphincter and radial muscles
iris
absence of the iris
aniridia
anterior compartment is the space between the ______ and iris and filled with _______ humor
cornea, aqueous
vitreous space is ______ to the lens and zonula attachments
posterior
blockage of the canal of Schlemm leading to increased intra orbital pressure
congenital glaucoma
forms from the otic vesicle, which develops from the surface ectoderm in the region of the hindbrain
inner ear
forms from the 1st branchial pouch (lining of tympanic cavity) and the 1st and 2nd branchial arches (malleus, incus, and stapes)
middle ear
develops from the 1st and 2nd branchial arches
external ear
caused by genetic factors (Treacher-Collins) or rubella or cytomegalovirus infection
congenital deafness
in middle ear, origin from 1st branchial pouch, proximal unexpanded portion forms auditory tube, distal portion forms tympanic cavity
tubotympanic recess
part of middle ear from 1st branchial arch
malleus and incus
part of middle ear from 2nd branchial arch
stapes
in development of the inner ear, thickening of surface ectoderm, developes a lumen and becomes the otic pit
otic placode
otic pit becomes otic _____
vesicle
______ portion of the inner ear gives rise to utricle, semicircular canals, endolymphatic duct and sac
utricular
______ portion of the inner ear gives rise to the saccule and cochlear duct
saccular
cavity in the temporal bone divided into 3 sections-vestibule, semicircular canals, and cochlea
bony labyrinth
lies within bony labyrinth and is divided into 3 parts-semicircular ducts, saccule, and utricle
membranous labyrinth
formation of perilymphatic space from the cartilaginous otic capsule which undergoes vacuolization, and scala tympani and vestibuli by vacuolization of otic capsule
formation of cochlear duct
organ of ______ contains hair cells receptors
corti