6/8/2023

Question 1

Paraplatin

Answer 1

Carboplatin

Question 2

Carboplatin MOA

Answer 2

Platinum compound alkylating agent which covalently binds to DNA; interferes with function of DNA by producing interstrand DNA cross-links

Question 3

Carboplatin class

Answer 3

Antineoplastic alkylating agent; platinum analog

Question 4

Kyprolis

Answer 4

Carfilzomib

Question 5

Carfilzomib class

Answer 5

Proteasome inhibitor

Question 6

Carfilzomib MOA

Answer 6

Inhibits proteasomes, which are responsible for intracellular protein homeostasis. Potent, selective, and irreversible inhibitor of chymotrypsin-like activity of the 20S proteasome, leading to cell cycle arrest and apoptosis

Question 7

BiCNU

Answer 7

Carmustine

Question 8

Carmustine class

Answer 8

Antineoplastic alkylating agent

Question 9

Gliadel wafer

Answer 9

Carmustine

Question 10

Carmustine MOA

Answer 10

Interferes with normal function of DNA and RNA by alkylating and cross-linking strands of DNA and RNA, and by possible protein modification. May also inhibit enzyme processes by carbamylation of amino acids in protein.

Question 11

Cefazolin MOA

Answer 11

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and preventing the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall.

Question 12

Cefazolin class

Answer 12

1st generation cephalosporin

Question 13

Cefepime

Answer 13

4th generation cephalosporin

Question 14

Cefepime MOA

Answer 14

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and preventing the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall.

Question 15

Fetroja

Answer 15

Cefiderocol

Question 16

Cefiderocol MOA

Answer 16

Siderophore cephalosporine. A catechol side chain promotes formation of chelated complexes with ferric iron, allowing use of iron transport systems to deliver the drug across the outer membrane of gram-negative bacilli. Cephalosporin moiety binds to penicillin-binding protein which inhibits the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall.

Question 17

Cefiderocol class

Answer 17

Siderophore cephalosporine

Question 18

Claforan

Answer 18

Cefotaxime

Question 19

Cefotaxime class

Answer 19

3rd generation cephalosporine

Question 20

Cefotaxime MOA

Answer 20

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and preventing the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall.

Question 21

Teflaro

Answer 21

Ceftaroline

Question 22

Ceftaroline class

Answer 22

5th generation cephalosporin (anti-MRSA cephalosporin)

Question 23

Ceftaroline MOA

Answer 23

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and preventing the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall.

Question 24

Avycaz

Answer 24

Ceftazidime/avibactam

Question 25

Ceftazidime class

Answer 25

Cephalosporin combination

Question 26

Ceftazidime/avibactam MOA

Answer 26

Ceftazidime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and preventing the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall.

Avibactam inactivates some beta-lactamases and protects ceftazidime from degradation.

Question 27

Zerbaxa

Answer 27

Ceftolozane/tazobactam

Question 28

Ceftolozane/tazobactam class

Answer 28

cephalosporin combination

Question 29

Ceftolozane/tazobactam MOA

Answer 29

Ceftolozane inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and preventing the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall.

Tazobactam irreversibly inhibits beta-lactamases.

Question 30

Ceftriaxone class

Answer 30

3rd generation cephalosporin

Question 31

Ceftriaxone MOA

Answer 31

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and preventing the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall.

Question 32

Ceftin

Answer 32

Cefuroxime

Question 33

Cefuroxime class

Answer 33

2nd generation cephalosporine

Question 34

Cefuroxime MOA

Answer 34

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and preventing the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall.

Question 35

Keflex

Answer 35

Cephalexin

Question 36

Cephalexin MOA

Answer 36

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and preventing the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall.

Question 37

Cephalexin class

Answer 37

1st generation cephalosporin

Question 38

D-Vi-Sol

Answer 38

Cholecalciferol (vitamin D3)

Question 39

Cholecalciferol class

Answer 39

Vitamin D analog

Question 40

Cholecalciferol MOA

Answer 40

Cholecalciferol is a provitamin. The active metabolite is calcitriol, which stimulates calcium and phosphate absorption from the small intestine, promotes secretion of calcium from bone to blood, and promotes renal tubule phosphate reabsorption.

Question 41

Ciprofloxacin class

Answer 41

Fluoroquinolone

Question 42

Ciprofloxacin MOA

Answer 42

Inhibits DNA-gyrase in susceptible organisms; inhibits relaxation of supercoiled DNA and promotes breakage of double-stranded DNA.