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Top 300 Drugs > 6/14/2023 > Flashcards

6/14/2023 Flashcards

1
Q

Emend

A

Fosaprepitant

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2
Q

Fosaprepitant MOA

A

Prodrug of aprepitant; substance P/neurokinin 1 (NK1) receptor antagonist. Prevents acute and delayed vomiting by inhibiting substance P/neurokinin 1 (NK1) receptor.

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3
Q

Fosaprepitant class

A

Substance P/neurokinin 1 receptor antagonist

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4
Q

Foscavir

A

Foscarnet

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5
Q

Foscarnet class

A

antiviral

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6
Q

Foscarnet MOA

A

Pyrophosphate analog which acts as a noncompetitive inhibitor of many viral RNA and DNA polymerases as well as HIV reverse transcriptase

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7
Q

Cerebyx

A

Fosphenytoin

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8
Q

Fosphenytoin MOA

A

Prodrug of phenytoin; works by stabilizing neuronal membranes and decreasing seizure activity by increasing efflux and decreasing influx of sodium ions across cell membranes.

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9
Q

Fosphenytoin class

A

Antiseizure agent

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10
Q

Faslodex

A

Fulvestrant

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11
Q

Fulvestrant MOA

A

Estrogen receptor antagonist; competitively binds to estrogen receptors on tumors and other tissue targets, producing a nuclear complex that causes a dose-related down-regulation of estrogen receptors and inhibits tumor growth

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12
Q

Fulvestrant class

A

estrogen receptor antagonist (antineoplastic)

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13
Q

Neurontin

A

Gabapentin

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14
Q

Gabapentin MOA

A

Structurally related to GABA, but does not bind to GABA receptors. Gabapentin binding sites correspond to presynaptic voltage-gated calcium channels, and may modulate the release of excitatory neurotransmitters.

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15
Q

Gabapentin class

A

miscellaneous antiseizure agent

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16
Q

Cytovene

A

Ganicyclovir

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17
Q

Ganicyclovir MOA

A

Phosphorylated to ganicyclovir triophosphate, which competes against the natural substrate for incorporation into DNA, resulting in inhibition of viral DNA synthesis.

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18
Q

Ganicyclovir class

A

antiviral

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19
Q

Infugem

A

Gemcitabine

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20
Q

Gemcitabine MOA

A

Pyrimidine antimetabolite; inhibits DNA synthesis by inhibition of DNA polymerase and ribonucleotide reductase. Cell cycle specific to S-phase.

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21
Q

Gemcitabine class

A

Pyrimidine analog antimetabolite (antineoplastic)

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22
Q

Copaxone

A

Glatiramer

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23
Q

Glatiramer MOA

A

Mimics the myelin basic protein. Thought to induce and activate T-cell suppressor cells specific for myelin antigen

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24
Q

Glatiramer class

A

miscellaneous biological

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25
Q

Mavyret

A

Glecaprevir/pibrentasvir

26
Q

Glecaprevir/pibrentasvir class

A

NS3/4A protease inhibitor/NS5A inhibitor (anti-HCV)

27
Q

Glecaprevir/pibrentasvir MOA

A

Glecaprevir - Inhibits HCV NS3/4A protease, which is necessary for the proteolytic cleavage of the HCV-encoded polyprotein and is essential for viral replication

Pibrentasvir - inhibits HCV NS5A, essential for viral RNA replication and virion assembly

28
Q

Zoladex

29
Q

Goserelin class

A

Gonadotropin-releasing hormone agonist (antineoplastic)

30
Q

Goserelin MOA

A

Causes an initial increase in luteinizing hormone (LH) and follicle stimulating hormone (FSH), chronic administration results in sustained suppression of pituitary gonadotropins. Depletes serum testosterone.

31
Q

Tremfya

A

Guselkumab

32
Q

Guselkumab MOA

A

Monoclonal antibody that selectively binds with IL-23, thereby reducing levels of IL-17A, IL-17F, and IL-22. Inhibits the release of proinflammatory cytokines and chemokines.

33
Q

Guselkumab class

A

Interleukin-23 inhibitor, monoclonal antibody

34
Q

Hydrochlorothiazide MOA

A

Inhibits sodium reabsorption in the distal tubules, causing increased excretion of sodium and water as well as potassium and hydrogen ions

35
Q

Zohydro

A

Hydrocodone

36
Q

Hydrocodone MOA

A

Binds opioid receptors in the CNS, causing inhibition of ascending pain pathways, altering the perception of and response to pain; produces generalized CNS depression

37
Q

Solu-Cortef

A

Hydrocortisone

38
Q

Hydrocortisone MOA

A

Short-acting corticosteroid with minimal sodium-retaining potential; decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability

39
Q

Hydroxychloroquine MOA

A

For RA - not fully understood; anti-inflammatory action: interferes with antigen processing in macrophages and other antigen-presenting cells

40
Q

Hydroxychloroquine class

41
Q

Idamycin

A

Idarubicin

42
Q

Idarubicin class

A

Anthracycline

43
Q

Idarubicin MOA

A

Inhibits DNA and RNA synthesis by intercalation between DNA base pairs and by steric obstruction.

44
Q

Ifex

A

Ifosfamide

45
Q

Ifosfamide MOA

A

Causes cross-linking of strands of DNA by binding with nucleic acids and other intracellular structures, resulting in cell death; inhibits protein synthesis and DNA synthesis

46
Q

Ifosfamide class

A

Alkylating agent (antineoplastic)

47
Q

Primaxin

A

Imipenem/Cilastatin

48
Q

Imipenem/Cilastatin MOA

A

Imipenem - carbapenem; inhibits bacterial cell wall synthesis by binding to one or more penicillin binding proteins, thereby inhibiting the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls.

Cilastatin - prevents renal metabolism of imipenem by competitive inhibition of dehydropeptidase along the brush border of the renal tubules; prolongs the activity of imipenem.

49
Q

Remicade

A

Infliximab

50
Q

Inflexa

A

Infliximab

51
Q

Avsola

A

Infliximab

52
Q

Infliximab MOA

A

Monoclonal antibody against TNF-alpha

53
Q

Infliximab class

A

Biologic DMARD (TNF-alpha)

54
Q

Venofer

A

Iron Sucrose

55
Q

Cresemba

A

Isavuconazole

56
Q

Isavuconazole MOA

A

Inhibits fungal CYP450; the enzyme responsible for conversion of lanosterol to ergosterol is dependent on CYP450, so this drug prevents the synthesis of ergosterol which is an essential component of the fungal cell wall.

57
Q

Isavuconazole class

A

Azole antifungal

58
Q

Taltz

A

Ixekizumab

59
Q

Ixekizumab MOA

A

Monoclonal antibody that binds with IL-17A cytokine and inhibits its interaction with the IL-17 receptor, thereby reducing the release of proinflammatory cytokines.

60
Q

Ixekizumab class

A

anti-IL17A monoclonal antibody

61
Q

Lacosamide MOA

A

Stabilizes hyperexcitable neuronal membranes and inhibits repetitive neuronal firing by enhancing slow inactivation of sodium channels

62
Q

Lacosamide class

A

Miscellaneous antiseizure agent

Top 300 Drugs (9 decks)

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