5 Antibiotic resistance problems in companion animals

Question 1

Which resistant bacteria cause therapeutic

problems in small animal and equine practice?

Answer 1

Pseudomonas aeruginosa

Staphylococcus aureus/pseudintermedius

Escherichia coli ESBL Both pets and horses

N.B. All these bacteria are resistant to β-lactams and often additionally resistant to fluoroquinolones

Question 2

Pseudomonas aeruginosa

hvilke dyr og ab?

Answer 2

Fluoroquinolones and aminoglycosides

Mainly dogs

Question 3

Staphylococcus aureus/pseudintermedius
MRSA/MRSP
hvilke dyr?

Answer 3

MRSA/MRSP

Both pets and horses

Question 4

What are the treatment options for infections

caused by multidrug-resistant (MDR) bacteria?

Answer 4

1. Whenever possible, use topical treatment
   • Shampo and antiseptic products
   • Fusidic acid (otitis and localized pyoderma)
2. Systemic therapy is necessarily guided by susceptibility data
3. Decisions (e.g. therapy vs. euthanasia) should
   take into consideration infection type, patient’s
   age, value and conditions

Question 5

Antibiotic options for systemic therapy

• Chloramphenicol - ulemper

Answer 5

• 10-40% resistance
• Difficult to find and expensive
• Q8 h (interval)

Question 6

Antibiotic options for systemic therapy

Rifampicin - ulemper

Answer 6

• Only in combination therapy

* Hepatotoxic

Question 7

Antibiotic options for systemic therapy

• Nitrofurantoin - ulemper

Answer 7

• Only UTI

Question 8

• Critically important antibiotics (CIAs) used in human hospitals

Answer 8

• Amikacin and carbapenems (ESBL)
• Linezolid and vancomycin (MRSP)
• Injectable drugs (inconvenient administration route for small animals)