4.Adenovirus_Flashcards
Where was Adenovirus first isolated?
From adenoids (tonsils).
What type of genome does Adenovirus have?
Linear dsDNA.
Describe the structure of Adenovirus.
Icosahedral, non-enveloped (naked), 70–90 nm in size.
What are the capsid features of Adenovirus?
Contains 12 vertices with 7 proteins (pentons and hexons).
How many proteins are encoded by the Adenovirus genome?
Approximately 30 proteins.
What are the stages of Adenovirus transcription?
Immediate early, early, and late stages.
What are the special features of Adenovirus capsid?
12 protein fibers with hemagglutination activity; globes mediate attachment.
How many serotypes of Adenovirus infect humans?
41 serotypes.
What are the main routes of Adenovirus transmission?
Fecal-oral route, respiratory droplets, direct contact (hand-to-eye), and venereal transmission.
What respiratory diseases are caused by Adenovirus?
Pharyngitis, pneumonia, ARDS (Acute Respiratory Distress Syndrome).
What is Pharyngoconjunctival fever, and how is it transmitted?
Adenovirus infection causing pink eye, often spread in swimming pools.
What serotypes cause ARDS in military recruits?
Serotypes 3, 4, 7, 21.
What gastrointestinal diseases are caused by Adenovirus?
Gastroenteritis (diarrhea) and hepatitis, especially in infants (serotypes 40, 41, 42).
What genitourinary diseases are caused by Adenovirus?
Urethritis, cervicitis, and hemorrhagic cystitis (serotypes 11, 21).
What serotypes cause Epidemic Keratoconjunctivitis?
Serotypes 8, 19.
What diagnostic methods are used for Adenovirus?
ELISA, Immunofluorescent Assay (IFA), and Isolation/Culture.
What is a cytopathic effect (CPE) in Adenovirus?
Basophilic intranuclear inclusion bodies, inhibition of macromolecular synthesis, and cell rounding.
Is there a specific treatment for Adenovirus?
No specific treatment; supportive care is provided. Ribavirin is a potential antiviral.
What type of vaccine is available for Adenovirus?
Live non-attenuated oral vaccine for high-risk groups (serotypes 4, 7, 21).
What preventive measures can reduce Adenovirus transmission?
Swimming pool chlorination, hand washing, and high ophthalmology hygiene.
What role does Adenovirus play in genetic therapy?
Used in gene replacement therapy, particularly for conditions like cystic fibrosis.
