10. HSV1_HSV2_Detailed_Flashcards

Question 1

What is the natural host and site of latency for HSV-1?

Answer 1

Humans are the natural host. Latency occurs in the trigeminal ganglia.

Question 2

What is the transmission method for HSV-1?

Answer 2

HSV-1 is transmitted through direct contact or saliva.

Question 3

What is the typical age group affected by HSV-1, and what type of infection does it cause?

Answer 3

HSV-1 commonly affects young children, causing orofacial infections.

Question 4

What symptoms/diseases are caused by HSV-1?

Answer 4

1. Vesicular rash (fluid-filled blisters).
2. Gingivostomatitis: Oral vesicles, often severe and recurrent.
3. Herpes Labialis: Cold sores/blisters.
4. Keratoconjunctivitis: Corneal ulcers, can lead to blindness.
5. Herpetic Whitlow: Painful pustules on fingers.
6. Encephalitis: Temporal lobe involvement with hemorrhagic necrosis (HMB).
7. Disseminated infection: Seen in immunocompromised patients (ICP).

Question 5

What is the natural host and site of latency for HSV-2?

Answer 5

Humans are the natural host. Latency occurs in the lumbosacral ganglia.

Question 6

What is the transmission method for HSV-2?

Answer 6

HSV-2 is transmitted through direct contact, sexual transmission (STD), or congenital transmission (via birth canal).

Question 7

What is the typical age group affected by HSV-2, and what type of infection does it cause?

Answer 7

HSV-2 commonly affects young adults, causing genital infections.

Question 8

What symptoms/diseases are caused by HSV-2?

Answer 8

1. Vesicular rash: Painful genital herpes in males and females, sometimes asymptomatic.
2. Neonatal herpes: Transmitted during birth via contact with vesicles in the birth canal, leading to:
   
   • Skin, eye, and mucous membrane involvement.
   • Generalized infection.
   • Encephalitis.
3. Aseptic meningitis: Neurological complication associated with HSV-2.

Question 9

What is the replication cycle duration for HSV?

Answer 9

HSV has a rapid replication cycle lasting 12-18 hours.

Question 10

What are the differences in transmission between HSV-1 and HSV-2?

Answer 10

HSV-1: Transmitted through direct contact or saliva.
HSV-2: Transmitted through direct contact, STD, or congenital transmission (birth canal).

Question 11

What are the sites of latency for HSV-1 and HSV-2?

Answer 11

HSV-1: Latent in the trigeminal ganglia.
HSV-2: Latent in the lumbosacral ganglia.