11. HSV_Diagnosis_Treatment_Flashcards

Question 1

How is HSV inactivated?

Answer 1

HSV is inactivated at room temperature and by drying.

Question 2

What are the diagnostic methods for HSV?

Answer 2

1. Cell Culture: Detects cytopathic effects, results in 1-3 days.
2. Serology (IFA/ELISA): Detects glycoproteins.
3. Tzanck Smear: Giemsa stain identifies syncytium formation and Cowdry type A inclusions.
4. CSF PCR: Used for encephalitis and aseptic meningitis.
5. Neutralization Test: Detects antibodies.

Question 3

What is seen on a Tzanck smear in HSV infections?

Answer 3

• Syncytium formation (ground-glass appearance).
• Cowdry type A inclusion bodies (Lipschutz bodies).

Question 4

What is the main drug for HSV treatment, and what are its effects?

Answer 4

• Acyclovir (Zovirax):
  
  • No effect on latent infection.
  • Reduces symptom duration and viral shedding.
  • Effective in encephalitis and systemic infections.
  • Does not prevent recurrences.

Question 5

Is there a vaccine for HSV?

Answer 5

No, there is currently no vaccine for HSV.

Question 6

What is the role of C-section in HSV prevention?

Answer 6

C-section is recommended for pregnant women with:
- Active genital vesicles.
- Positive HSV culture (to prevent neonatal transmission).