3. Parvovirus_B19_Flashcards
What is the size of Parvovirus B19?
22 nm, one of the smallest viruses.
What type of genome does Parvovirus B19 have?
Linear ssDNA, negative sense.
Describe the structure of Parvovirus B19.
Icosahedral, non-enveloped (naked).
Where does Parvovirus B19 replicate?
In mitotically active cells like erythroblasts; temporarily becomes dsDNA in the S-phase.
What is produced during Parvovirus B19 replication?
Both +ve and -ve sense strands; only -ve sense strands form infectious virions.
How long can Parvovirus B19 remain infective in the environment?
Months or years due to high resistance.
Who does Parvovirus B19 primarily affect?
Mainly children (6–10 years old), but adults can also be infected.
What are the main routes of transmission for Parvovirus B19?
Respiratory droplets (most common), bloodborne transmission, and transplacental transmission.
What is the significance of Parvovirus B19 in pregnancy?
Can cause hydrops fetalis, aplastic crises, miscarriage, or stillbirth but is not teratogenic.
What childhood disease is caused by Parvovirus B19?
Erythema infectiosum (fifth disease), presenting as a bright red rash on the cheeks (slapped cheek syndrome).
What condition does Parvovirus B19 cause in adults?
Seronegative arthritis.
What complications arise from Parvovirus B19 in immunocompromised patients?
Chronic anemia.
What is the secondary attack risk for Parvovirus B19?
0.5
What percentage of adults are immunized against Parvovirus B19?
50% of adults are seropositive.
What indicates immunity to Parvovirus B19?
Presence of IgG antibodies in serum; reinfection is rare but possible in a minority.
