42. Parkinson's disease Flashcards
1
Q
What is Parkinson’s disease?
A
A degenerative disorder of the CNS mainly affecting the motor system. Caused by death of dopamine-generating cells in the substantia nigra of the basal ganglia.
2
Q
Symptoms
A
Early: Shaking, rigidity, slowness of move. and difficulty with walking and gait.
Later: Thinking and behavioral problems, dementia, and depression
3
Q
Diagnosis
A
Neurological history and performs an exam.
No standard diagnostic tests
Good response to levodopa, CT/MRI to rule out other causes
4
Q
Treatment
A
- Drugs ↑dopamine: AMANTADINE, LEVODOPA + CARBIDOPA, RASAGILINE, SELEGILINE
- Dopamine rcpt agonists: APOMORPHINE, BROMOCRIPTINE, ROPINIROLE
- Cholinergic rcpt antagonists: BENZTROPINE, TRIHEXYPHENIDYL
5
Q
Causes
A
UNKNOWN
Genetic mutation in PINK1, PARKIN, ALPHA SYNUCLEIN
MPTP (found in recreational drug MPPP)
