4 - Healing & Fever Flashcards
3 Types of Healing
- resolution
- regeneration
- replacement
Resolution
-minimal tissue damage
-tissue returns to normal in short period
of time
Example: mild sunburn
Regeneration
Replacement of injured tissue with cells of the
same parenchymal type leaving little or no
evidence of injury
Example: epithelial cells and liver cells
Replacement
Extensive damage of tissue /
cells which do not regenerate
* replaced by connective
tissue (scar/fibrous tissue)
More common in chronic
conditions….
Example: brain or myocardium
Labile cells
- cells which continue to divide and replicate throughout
life
Results: no or little evidence of injury
Example: epithelial layers skin
oral cavity
Regeneration and Replacement of 3 types of body cells
Labile cells, stable cells, permanent or fixed cells
Stable cells
Stop dividing when growth ceases, but will regenerate if injured
Permanent/fixed cells
Cannot regenerate
Stages of healing
- Inflammatory phase
- Proliferative phase
- Remodeling phase
Complications of scar formation
- Loss of Function
- Contractures and Obstructions
- Adhesions
- Hypertrophic Scar Tissue
- Ulceration
Normal temperature range
36.0 - 37.5 °C
-97.0 - 99.5°F
How is temperature regulated
Thermoregulatory center located in hypothalmus
Thermostatic set point regulates:
- core temperature
Fever/pyrexia
Elevation in body temperature caused by increased set point of the hypothalamic thermoregulatory centre
Purpose of fever (3)
- Signals presence of disease
- Enhance immune function:
- increased motility and activity of WBC’s - The growth of most M/O’s:
normal in temp range
inhibited in fever range
FUO
Fever of Unknown Origin
- ↑temp 38.3 °C (101 °F ) or higher
- 3 weeks or longer
- Unknown origin
