4-Basal Nuclei Flashcards

1
Q

function

A
  1. inhibit involuntary movements at rest
  2. facilitate voluntary movements
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2
Q

inhibited movements

A
  1. tremors- rhythmi, distal extremities
  2. chorea- random jerky
  3. tics- brief action preceded by irresistable urge
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3
Q

facilitated movements

A
  1. starting movements- getting up chair, start walking
  2. keeping/maintaining- speed of action
  3. stopping an action- stop and turn
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4
Q

major nuclei of basal

A
  1. caudate nucleus
  2. putamen
  3. globus pallidus/pallidum
  4. subthalamic nucleus
  5. substantia nigra

1-3 = corpus striatum, 2 + 3 = lentiform nucleus

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5
Q

striatum =

A

putamen + caudate nucleus

more functional description NOT short term for corpus striatum

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6
Q

input to striatum

A
  1. corticostriate fibers
  2. nigrostriate fibers (substantia nigra)
  3. thalamostriate fibers

nigrostriate has dopamine neurons, lose in parkinsons

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7
Q

output from striatum

A
  1. striatopallidal fibers
  2. striatonigral fibers
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8
Q

input to pallidum

A
  1. striatopallidal
  2. subthalamic nucleus
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9
Q

output from pallidum

A
  1. pallidothalamic fibers aka thalamic fasiculus = lenticular fasiculus + ansa lenticularis + subthalamic fasiculus

to VA/VL nuclei (motor)

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10
Q

closed motor loop sequence

A
  1. supplementary motor cortex
  2. caudate nucleus and putamen (striatum) input gate
  3. globus pallidus/pallidum + substantia nigra output gate
  4. ventral lateral (VL) nucleus of thalamus
  5. repeat
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11
Q

open motor loop

input into closed loop

A
  1. somatosensory cortex
  2. primary motor cortex- execution
  3. premotor cortex- orientation

all feed into closed loop/striatum via corticostriate fibers

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12
Q

closed association loop

A
  1. prefrontal cortex- plan and decide
  2. striatum
  3. pallidum
  4. thalamus- VA (ventral anterior), dorsomedial nucleus
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13
Q

open association loop/input

A
  1. premotor cortex (orientation)
  2. posterior parietal cortex (visual guidance)
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14
Q

oculomotor closed loop

A
  1. frontal eye field-visual tracking
  2. striatum
  3. pallidum
  4. VA + dorsomedial nucleus thalamus OR superior colliculus for reflexes
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15
Q

oculomotor open loop

A

input from
1. prefrontal cortex- plan and decide
2. posterior parietal cortx- visual guidance

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16
Q

limbic closed loop

A
  1. anterior cingulate gyrus + orbitofrontal cortex
  2. striatum (ventral, nucleus accumbens)
  3. pallidum
  4. VA + dorsomedial nucleus thalamus
17
Q

limbic open loop

A
  1. medial and lateral temporal lobe
  2. hippocampus-memory
  3. amygdala- fear, emotions
  4. entorhinal area- olfactory
18
Q

direct pathway

A

striatum > substantia nigra
and back

general excitation of basal nuclei (hyperkinesia)

19
Q

indirect pathway

A

pallidum > subthalamus via subthalamic fasciculus

inhibitory to basal nuclei (hypokinesia)

20
Q

thalamus is what to cortex

A

excitatory

21
Q

pallidum is waht to thalamus

A

inhibitory

22
Q

why no paralysis

A

bc no tracts are going to muscles