35 - Paramyxoviridae, Pneumoviridae

Question 1

Paramyxoviridae

Answer 1

• Etymologi:
  
  • Para: like
  • Myxa: mucous
• Morphology:
  
  • ​-ssRNA genome
  • Helical capsid
  • Enveloped
• Resistance: weak (pH, heat, detergents)​
• Biological properties:
  
  • Baltimore V. - viral transcriptase
  • proteins:
    
    • Hemagglutinin and neuraminidase activity
    • Fusion proteins
  • CPE: cytoplasmic inclusion bodies, syncytia, haemadsorption
  • Euryxen:
    
    • Respirovirus
    • Rubulavirus
    • Avulavirus
    • Heipavirus
  • More stenoxen:
    
    • Morbillivirus
    • Pneumovirinae
• Antigenic properties:
  
  • ​Good antigens
  • Cross-reactions within genera (Morbillivirus genus)
• Diagnosis:
  
  • ​Isolation: HA, IF
  • Indirect: VN, HAI

Question 2

Paramyxoviridae

List the different genera

Answer 2

• Respirovirus genus
• Morbillivirus genus
• Rubulavirus genus
• Avulavirus genus
• Henipavirus genus
• Ferlavirus genus
• Aquaparamyxovirus genus

Question 3

Paramyxoviridae

Respirovirus genus

Answer 3

• Respiratory disease
• Parainfluenza virus 1
  
  • ​Human
  • Influenza-like disease
• Parainfluenzavirus 3
  
  • ​Cattle, sheep
  • Shipping fever

Question 4

Paramyxoviridae

Morbillivirus genus

Answer 4

• Morbilli: measles
• Canine distemper virus
  
  • ​Dogs and other carnivores (ø cats)
  • Fever and respiratory symptoms
  • Chronic → encephalitis of CNS
• Rinderpest
  
  • ​Ruminants
  • Fever, hemorrhage, mucosal erosins
  • Extinct since 2012
• Measles (morbilli)
  
  • ​Human
  • Fever, rash

Question 5

Paramyxoviridae

Rubalvirus genus

Answer 5

• Rubula inflans: mumps
• Paranifluenzavirus 1
  
  • ​Dog: kennel cough
  • Human: influneza-like disease
• ​Paranifluenzavirus 4
  
  • ​Human: influneza-like disease

Question 6

Paramyxoviridae

Avulavirus genus

Answer 6

• Avis
• Newcastle disease (avian paramyxovirus 1)
  
  • ​Euryxen: birds, zoonosis
  • Several strains
• Avian paramyxovirus 2-9
  
  • ​2-6: some strains are pathogen in pets and wild birds
  • 7-9: orphan

Question 7

Paramyxoviridae

Henipavirus genus

Answer 7

• Hendra virus
  
  • ​Horse, human
• Nipah virus
  
  • ​Swine, human

Question 8

Paramyxoviridae

Ferlavirus genus

Answer 8

• Fer-de-Lance virus
  
  • ​Snake pneumonia

Question 9

Paramyxoviridae

Aquaparamyxoviridae genus

Answer 9

Atlantic salmon paramyxovirus

Question 10

Pneumoviridae

Answer 10

• Etymologi: pneuma: air
• Morphology:
  • ​-ssRNA genome
  • Non-segmented

Question 11

Pneumoviridae

List the different generas

Answer 11

• Orthopneumovirus genus
• Metapneumovirus genus

Question 12

Pneumoviridae

Orthopneumovirus genus

Answer 12

• Bovine respiratory syncytial virus
  
  • ​Severe pneumonia
  • Interstitial emphysema
• Ovine respiratory synchitial virus
• Murine pneumonia
  
  • ​Mice
• Human respiratory syncytial virus

Question 13

Pneumoviridae

Metapneumovirus genus

Answer 13

• Turkey rhintrachealis virus
• Swollen head syndrome
  
  • ​Chicken