26 - Herpesviridae Flashcards
1
Q
Herpesviridae
- Etymology
- Morphology
- Resistance
- Biological properties
- Diagnosis
A
- Etymology: Herpes: pertant, crawler
-
Morphology:
- Linear dsDNA
- Capsid within envelope
- Resistance: Weak (detergents, heat)
-
Biological properties:
- Latent infections: episoma, integration
- Strong CPE
- Intranuclear inclusion bodies
- Syncytia
- Cell rounding, lysis
- Ocogenity (mainly gammaherpesviruses)
- Henerally stenoxen
-
Antigenic properties:
- Weak immunogens
- Cross reaction within genera
- Aujeszky’s disease – IBR
- EHV-1 – EHV-4
- Marek’s disease – turkey herpes
-
Diagnosis:
- Isolation
- NA-hybridization, PCR
- VN for identification
2
Q
Herpesviridae
List the subfamilies and their genera
A
-
Aphaherpervirinae:
- Simplexvirus
- Varicellovirus
- Mardivirus
- Litovirus
-
Betaherpesvirinae:
- Cytomegalovirus
- Muromegalovirus
- Proboscivirus
- Roseolovirus
-
Gammaherpervirinae:
- Lymphocryptovirus
- Rhadinovirus
- Macavirus
- Percavirus
- Difference in:
- Replication time
- Latency site (ganglia, glands, macrophages, lymphocytes)
- Cytopathic effects (inclusion bodies, cytomegaly, fusion)
3
Q
Alphaherpesvirinae
Simpexvirus genus
A
- Bovine herpesmamillitis (BoHV-2)
-
Simian herpes (B-virus)
- Often lethal to humans, encephalitis
-
Human herpes simplex (HHV 1-2)
- Labial and genital herpes - keratitis, encephalitis
- Cow teats
4
Q
Alphaherpesvirinae
Varicellovirus genus
A
- Infectious bovine rhinotracheitis (IBR, BoHV-1, BoHV-5)
- Equine abortion/rhinopneumonitis (EHV-1, EHV-4, EHV-6)
-
Coital exanthema (EHV-3)
- Swine: abortion, respiratory and CNS signs
- Other species: lethal CNS disease, similar to rabies
-
Pseudorabies: aujezkys disease (SuHV)
- Swine: abortion, respiratory and CNS sings
- Other species: lethal CNS disease, rabies
-
Canine herpesvirus (CHV-1)
- Nasal mucosa
- Feline rhinotracheitits (FeHV-1)
- Deer, reideer, buffalo, monkey, seal herpesviruses
-
Human varicella - zoster (HHV-3)
- Chickenpox - shingles
- Rhinotracheitis, abortion
- Infectious pustular vulvovaginitis (IPV)
- Balanopostitis (IBP)
5
Q
Alphaherpesvirinae
Mardivirus genus
A
-
Marek’s disease virus (GaHV 2-3)
- CNS sings, prarlysis
- Lymphatic tumors
- Turkey herpesvirus (MeHV-1)
6
Q
Alphaherpesvirinae
Litovirus genus
A
Infectious laryngotracheitis (GaHV-1)
7
Q
Betaherpesvirinae
Cytomegalovirus geuns
A
- Human cytomegalovirus
- Monkey cytomegalovirus
8
Q
Betaherpesvirinae
Muromegalovirus genus
A
- Muse, rat cytomegaloviruses
-
Proboscivirus genus:
- Elephant cytomegalovirus
-
Roseolovirus genus:
-
Human: roseola infectiosa (HHV 6,7)
- Fever for children
- Rash
-
Human: roseola infectiosa (HHV 6,7)
9
Q
Betaherpesvirinae
Proboscivirus genus
A
Elephant cytomegalovirus
10
Q
Betaherpesvirinae
Roseolovirus genus
A
-
Human: roseola infectiosa (HHV 6,7)
- Fever for children
- Rash
11
Q
Gammaherpse virus
Lymphocryptovirus genus
A
- Epstein-Barr virus (HHV-4)
-
Baboon, monkey, ape herpesviruses
- Mononucleosis infectiosa
- Burkitt’s lymphoma
- Nasopharyngeal carcinoma
12
Q
Gammaherpse virus
Rhadinovirus genus
A
- Bovine herpesvirus 4 (Movar): Pneumonia
-
Kaposi’s sarcoma-associated herpesvirus (HHV-8)
- Human, in immunosuppressant patients
- Rodent, ruminant herpesviruses
13
Q
Gammahepse virus
Macavirus genus
A
-
__Malignant catarrhal fever of cattle (AlHV-1, OvHV-2)
- Wildbeest, sheep - asymptomatic carrier
14
Q
Gammahepse virus
Percavirus genus
A
-
Equine herpesvirus 5
- Pulmonary fibrosis
-
Equine herpesvirus 2
- Foal pneumonia + Rh. equi
15
Q
Give the unassinged herpesviruses
A
- Swine inclusion body rhinitis (SuHV-2)
- Duck plague (AnHV-1)
- Pigeon herpes
- Pacheco’s disease - parrot hepatitis
