3.4 Soft Tissue Tumors

Question 1

• benign smooth muscle tumor
• often arises in the uterus (fibroid)
• histo: intersecting spindle cells with blunt end elongated nuclei, minimal atypia, few mitosis
• treat by surgical removal

Answer 1

leiomyoma

Question 2

characteristic histo finding of leiomyoma is ____________ nuclei

Answer 2

blunt-ended elongated

Question 3

• women > men
• develop in skin, deep soft tissues of extremities and retroperitoneum
• histo: malignant spindle cells with cigar-shaped nuclei, frequent mitosis and necrosis

Answer 3

leiomyosarcoma

Question 4

• vascular tumor, majority are superficial lesions (head, neck) but can occur internally (liver)
• capillary, cavernous, and pyogenic granuloma (lobular capillary) are subtypes

Answer 4

hemangioma

Question 5

type of hemangioma that has exophytic nodule, on skin, ginigiva or oral mucosa, often ulcerated with extensive inflammation

Answer 5

pyogenic granuloma (lobular capillary hemangioma)

Question 6

• low to intermediate grade vascular sarcoma
• 4 forms, 95% infected with HHV-8 aka KSHV
• transmitted sexually, tumor progression requires a cofactor (such as HIV)

Answer 6

Kaposi sarcoma

Question 7

What are the 3 stages of Kaposi sarcoma?

Answer 7

patches, plaques, nodules

Question 8

• vascular tumor
• older adults, involving skin, soft tissue, breast, and liver
• association with radiation
• histo: vascular channels lined with plump anaplastic endothelial cells

Answer 8

angiosarcoma

Question 9

________ angiosarcoma associated with chemical carcinogens (arsenic, thorotrast, polyvinyl chloride)

Answer 9

hepatic

Question 10

_________ angiosarcoma associated with lymphedema following axillary lymph node dissection in radical mastectomy

Answer 10

upper extremity

Question 11

• cell origin unclear
• age 20-40
• deep soft tissue around large joints of extremities
• chromosomal translocation (x;18)

Answer 11

synovial sarcoma

Question 12

synovial sarcoma is a biphasic tumor with both __________ and _________ components

Answer 12

epithelial, mesenchymal

Question 13

• proximal extremities and retroperitoneum
• large grey-white unencapsulated masses in musculature
• histo: malignant spindle cells in storiform pattern, high cytological pleomorphism, bizarre multinucleated cells

Answer 13

undifferentiated pleomorphic sarcoma (malignant fibrous histiocytoma)