2.7 Bone Tumor Pathology

Question 1

osteosarcoma is a malignant proliferation of __________

Answer 1

osteoblasts

Question 2

Peak incidence of osteosarcoma is in what age group?

Answer 2

teenagers, less commonly seen in elderly

Question 3

• Risk factors for this bone tumor are familial retinoblastoma, Paget disease, and radiation exposure
• commonly in metaphysis of the knee, malignant cells make osteoid

Answer 3

osteosarcoma

Question 4

This bone tumor arises in the metaphysis of long bones, usually the distal femur or proximal tibia, and presents as a pathologic fracture or bone pain with swelling

Answer 4

osteosarcoma

Question 5

imaging of this bone tumor reveals a destructive mass with a “sunburst” appearance and lifting of the periosteum

Answer 5

osteosarcoma

Question 6

malignant hyaline and mixoid cartilage forming tumor that arises in medulla of pelvis or central skeleton (pelvis, shoulder, ribs), typically 40 years or older

Answer 6

chondrosarcoma

Question 7

Ewing sarcoma is a malignant proliferation of poorly-differentiated cells derived from _____________

Answer 7

neuroectoderm

Question 8

This bone tumor arises in the diaphysis of long bones, usually in male children less than 15 years of age, 2nd mot common bone tumor in children

Answer 8

Ewing Sarcoma

Question 9

Biopsy of this bone tumor reveals small, round blue cells that resemble lymphocytes (can be confused with lymphoma or chronic osteomyelitis), 11;22 translocation is characteristic

Answer 9

Ewing sarcoma

Question 10

more common than primary tumors, usually result in osteolytic (punched out) lesions, prostatic carcinoma classically produces osteoblastic lesions

Answer 10

metastatic tumors

Question 11

• pancytopenia, proteinuria, lytic lesion in skull and spine, excess IgGk
• osteoblast inhibition, releases IL-1, activates osteoclasts
• lots of plasma cells on histo
• blacks, 50-60 yo

Answer 11

multiple myeloma (plasmacytoma if singular)

Question 12

-presents with fever/chills, common in children, responds to chemo
-small round blue cells on histo
(11;22) translocation

Answer 12

Ewing’s Sarcoma