2.12 Skin Pathology

Question 1

acquired mole, benign neoplasm of melanocytes

Answer 1

acquired benign melanocytic nevi

Question 2

nests of melanocytes at the dermal-epidermal junction, most common mole in children

Answer 2

junctional nevus

Question 3

melanocytes in the dermis only, exophytic mole with globular pigment

Answer 3

dermal nevus

Question 4

melanocytes in the dermis and epidermis

Answer 4

compound nevus

Question 5

fried egg appearance on skin, precursor to melanoma (?)

Answer 5

dysplastic nevus

Question 6

malignant neoplasm of melanocytes, most common cause of death from skin cancer

Answer 6

melanoma

Question 7

ABCDE of melanoma?

Answer 7

A: asymmetry, B: border irregularity, C: color variegation, D: diameter >5mm, E: evolving

Question 8

most common subtype of melanoma, dominant early radial growth results in good prognosis, classic ABCDE

Answer 8

superficial spreading melanoma

Question 9

lentiginous spreading (radial growth), good prognosis, in epidermis, from sun damage

Answer 9

Lentigo maligna melanoma

Question 10

early vertical growth, expansile dermal proliferation of melanocytes, ulcerated, necrosis, frquent mitosis, RAS mutations,

Answer 10

nodular melanoma

Question 11

arises on palms or soles, often dark skinned individuals, not related to UV light exposure, uncommon

Answer 11

acral lentiginous

Question 12

epithelial neoplasm, “liver spots”, tumor of pigmented keratinocytes (NOT melanocytes), reflection of sun damage, high pigmentation in rete ridges

Answer 12

solar lentigo

Question 13

• “brown bubblegum”, benign squamous proliferation, common tumor in elderly
• raised, discolored plaques on extremities or face, warty plaques
• keratin horn cysts on histology
• Leser-Trelat sign is sudden onset, suggests carcinoma of GI tract

Answer 13

seborrheic keratosis

Question 14

red scaly papule, precursor to squamous cell carcinoma, sun damage, blue/pink sign, orthokeratin

Answer 14

actinic keratosis

Question 15

• malignant proliferation of squamous cells characterized by formation of keratin pearls
• ulcerated, nodular mass, usually on face
• treat w/ excision, metastasis uncommon
• AK a precursor lesion

Answer 15

squamous cell carcinoma

Question 16

• malignant proliferation of basal cells of the epidermis, most common cutaneous malignancy
• elevated nodule, central ulcerated crater, telangiectasias, pink pearl like papule
• classic location is upper lip

Answer 16

basal cell carcinoma

Question 17

occluded hair follicles, filled with loose keratin, granular layer in the cyst wall

Answer 17

epidermoid cyst