3.3.13-Amino Acids, Protein, DNA Flashcards

1
Q

Show basic structure of amino acid

A

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2
Q

Show a low pH amino acid ion

A

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3
Q

Show high pH amino acid ion

A

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4
Q

Show zwitter ion

A

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5
Q

What does an amino acid and NaOH make

A

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6
Q

What does amino acid and HCl make

A

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7
Q

What does amino acid and ethanol make and conditions

A

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8
Q

What does amino acid and ethanoyl chloride make

A

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9
Q

What is the primary structure of proteins

A

Polypeptide chain
Specific order of amino acids
Joined by peptide bonds

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10
Q

What is secondary structure of proteins

A

How polypeptide chains interact
Hydrogen binding
Alpha helix’s , beta pleated sheets

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11
Q

What is tertiary structure of proteins

A

Chains fold into particular shape due to attractions on side chains = hydrogen bonding = disulphide bridges

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12
Q

What is Quartenary structure of proteins

A

More than 1 polypeptide chain

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13
Q

Identifying amino acids

A

Thin layer chromatography
Use ninhydrin and Uv light
Identified by Rf values

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14
Q

How do you work out Rf values

A

Distance travelled
————————-
Distance solvent went

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15
Q

What are types of proteins

A

Globular

Fibrous

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16
Q

What is importance of active site

A

Tertiary structure forms specific active site to substrate they can catalyse

17
Q

Explain competitive inhibitors

A

Competed for active site with substrate

Overcome by adding more substrate

18
Q

Explain non-competitive

A

Attaches somewhere else on enzyme

Changes tertiary structure so substrate no longer fits active site

19
Q

What is drug stereo specificity

A

Medicine molecules must be in correct enantiomeric form to work

20
Q

What is computer aided drug design

A

Predicts results of drugs

Interactions

21
Q

Structure of nucleotide

22
Q

What are features of DNA

A

Antiparallel strand

Complimentary base pairs -(A+T, C+G )

23
Q

What are the purines

24
Q

What are pyrimidines

25
What is DNA replication
DNA must be copied for cell division DNA helicase unzips DNA polymerase joins = semi-conservative replication
26
Show structure of cisplatin
Draw
27
What is purpose of Cisplatin and side effects
Kills cancer cells by binding to DNA and interfering with its repair causing cell death Side effects - renal toxicity, neurotoxicity, bone marrow supression
28
What is transplantin
Draw and it is not useful