33. Immunopharmacology II. (Antibodies and fusion proteins)

Question 1

What kind of antibody groups are there?

Answer 1

• IVIG
• Polyclonal antibodies
• Monoclonal antibodies
  
  • Antibodies against T cells
  • Antibodies against B cells
  • Antibodies against TNF alpha
  • Antibodies against cytokines
  • Antibodies against integrins
  • Others..

Question 2

Which are the polyclonal antibodies?

Answer 2

• Anti-lymphocyte globulin (ALG)
• Anti-thymocyte globulin (ATG)

Question 3

Which are the monoclonal antibodies against T cells?

Answer 3

• Muromonab-CD3
• Basiliximab
• Daclizumab

Question 4

Which are the monoclonal antibodies against B cells?

Answer 4

• Rituximab
• Ocrelizumab
• Alemtuzumab

Question 5

Which are the monoclonal antibodies against TNF alpha?

Answer 5

• Adalimumab
• Certolizumab pegol
• Etanercept
• Golimumab
• Infliximab

Question 6

Which are the monoclonal antibodies for cytokines?

Answer 6

• IL-1 receptor antagonist:
  
  • Anakinra
• Anti-IL1beta antibody:
  
  • Canakinumab
  • Rilonacept
• Anti-IL-5 antibody:
  
  • Reslizumab
• Anti-IL-6 receptor antibody:
  
  • Tocilizumab
  • Sarilumab
• Anti-IL-17 antibody:
  
  • Secukinumab
  • Ixekinumab
  • Brodalumab
• Anti-IL-12/23 antibody:
  
  • Ustekinumab
• Anti-IL-23 antibody:
  
  • Guselkumab
• ​​Anti-B lymphocyte stimulator protein (BLyS) antibody:
  
  • ​​Belimumab

Question 7

Which are the monoclonal antibodies for integrins?

Answer 7

• Natalizumab
• Vedolizumab

Question 8

What other monoclonal antibodies are there?

Answer 8

• Omalizumab
• Eculizumab

Question 9

Which fusion proteins are there?

Answer 9

Abatacept